New topics in bradykinin research

M. Maurer, M. Bader, M. Bas, F. Bossi, M. Cicardi, M. Cugno, P. Howarth, A. Kaplan, G. Kojda, F. Leeb-Lundberg, J. Lötvall, M. Magerl

Research output: Contribution to journalArticle

Abstract

Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B 1 and B 2 receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.

Original languageEnglish
Pages (from-to)1397-1406
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume66
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • angioedema
  • bradykinin
  • C1 esterase inhibitor
  • icatibant

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Maurer, M., Bader, M., Bas, M., Bossi, F., Cicardi, M., Cugno, M., Howarth, P., Kaplan, A., Kojda, G., Leeb-Lundberg, F., Lötvall, J., & Magerl, M. (2011). New topics in bradykinin research. Allergy: European Journal of Allergy and Clinical Immunology, 66(11), 1397-1406. https://doi.org/10.1111/j.1398-9995.2011.02686.x