New trends in coronary artery disease

the role of granulocyte activation

Giovanni Ricevuti, Antonino Mazzone, Stefano De Servi, Giuseppe Specchia, Pietro Fratino

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Circulating granulocytes play an important role in microvascular perfusion and organ pathology. Oxygen radicals released by aggregated and activated neutrophils may exacerbate the tissue damage caused by ischemia. We studied neutrophil aggregation and oxygen metabolites release in 16 patients suffering from coronary artery disease and in 6 control subjects in aorta and coronary sinus blood samples. The neutrophil aggregation (P <0.01) and oxidase activity (P <0.01) are higher in coronary sinus than aorta samples only in the patients with respect to controls. While the superoxide generation is decreased in coronary sinus (P <0.05). Our aggregation assay supported the potential role of granulocytes in neutrophil-endothelial interactions and tissue damage, and our results about oxidase activity and superoxide release suggested the potential role for neutrophil-derived oxygen radicals in the pathogenesis of vascular injury in vivo.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalAtherosclerosis
Volume78
Issue number2-3
DOIs
Publication statusPublished - 1989

Fingerprint

Granulocytes
Coronary Artery Disease
Neutrophils
Coronary Sinus
Superoxides
Aorta
Reactive Oxygen Species
Oxidoreductases
Vascular System Injuries
Endothelium
Ischemia
Perfusion
Pathology
Oxygen

Keywords

  • Adrenochrome
  • Aggregation
  • Coronary artery disease
  • Granulocyte
  • Leukotriene
  • Superoxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

New trends in coronary artery disease : the role of granulocyte activation. / Ricevuti, Giovanni; Mazzone, Antonino; De Servi, Stefano; Specchia, Giuseppe; Fratino, Pietro.

In: Atherosclerosis, Vol. 78, No. 2-3, 1989, p. 261-265.

Research output: Contribution to journalArticle

Ricevuti, Giovanni ; Mazzone, Antonino ; De Servi, Stefano ; Specchia, Giuseppe ; Fratino, Pietro. / New trends in coronary artery disease : the role of granulocyte activation. In: Atherosclerosis. 1989 ; Vol. 78, No. 2-3. pp. 261-265.
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