Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare

Translated title of the contribution: New trends in multimodal therapy of primitive gastric lymphoma

C. M. Franciosi, C. Angelini, C. Mussi, P. Sartori, F. Romano, S. De Fina, F. Uggeri

Research output: Contribution to journalArticle

Abstract

Background. Primitive gastric lymphoma (PGL) is a rare tumour, and although its incidence is rising it is difficult to state the role of the various therapeutic methods in treating this disease. Aim of this study is to point out what sequence of treatment is more effective trying to find out some guidelines which can be useful in clinical practice. Methods. Retrospective analysis of clinical data of 54 patients with PGL admitted at a University surgical department during 10 years. All the patients underwent neoadjuvant or adjuvant chemotherapy and D2 gastrectomy. Follow-up ranged from 6 to 120 months. Survival was related to: Mushoff's stage of disease, the grade according to the Working Formulation and the sequence of treatment. Statistical analysis was performed by Kaplan-Maier method and the difference between survival curves was compared by log-rank test. Results. Mean postoperative hospital stay was 12 days and morbidity was 18%. Five and 10 years overall survival rates were 70 and 85%. There was a significant difference in survival between patients with high grade PGL and those with intermediate grade (p=0.0188) as well as in those with low grade (p=0.0435). Patients in stages IE-II1E had a significantly longer survival than those in stages IIIE-IVE (p=0.0123). Patients in stages IE-II1E underwent neadjuvant chemotherapy and surgery and survived longer than those in whom surgery preceded chemotherapy (p=0.0293) instead for patients in stages IIIE-IVE neoadjuvant chemotherapy shortened survival (p=0.0403). Conclusions. In personal opinion, in patients in stages IE-II1E chemotherapy should be carried out before surgery, while in those in stages IIIE-IVE the reverse scheme is more effective in achieving longer survival rates.

Original languageItalian
Pages (from-to)337-343
Number of pages7
JournalMinerva Chirurgica
Volume56
Issue number4
Publication statusPublished - 2001

Fingerprint

Survival
Drug Therapy
Therapeutics
Survival Rate
Gastrectomy
Adjuvant Chemotherapy
Familial primary gastric lymphoma
Length of Stay
Guidelines
Morbidity
Incidence
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Franciosi, C. M., Angelini, C., Mussi, C., Sartori, P., Romano, F., De Fina, S., & Uggeri, F. (2001). Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare. Minerva Chirurgica, 56(4), 337-343.

Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare. / Franciosi, C. M.; Angelini, C.; Mussi, C.; Sartori, P.; Romano, F.; De Fina, S.; Uggeri, F.

In: Minerva Chirurgica, Vol. 56, No. 4, 2001, p. 337-343.

Research output: Contribution to journalArticle

Franciosi, CM, Angelini, C, Mussi, C, Sartori, P, Romano, F, De Fina, S & Uggeri, F 2001, 'Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare', Minerva Chirurgica, vol. 56, no. 4, pp. 337-343.
Franciosi CM, Angelini C, Mussi C, Sartori P, Romano F, De Fina S et al. Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare. Minerva Chirurgica. 2001;56(4):337-343.
Franciosi, C. M. ; Angelini, C. ; Mussi, C. ; Sartori, P. ; Romano, F. ; De Fina, S. ; Uggeri, F. / Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare. In: Minerva Chirurgica. 2001 ; Vol. 56, No. 4. pp. 337-343.
@article{26e94e2a1b4c4847a9db1a06ff1d3466,
title = "Linfoma a localizzazione gastrica. Attualit{\`a} nel trattamento multidisciplinare",
abstract = "Background. Primitive gastric lymphoma (PGL) is a rare tumour, and although its incidence is rising it is difficult to state the role of the various therapeutic methods in treating this disease. Aim of this study is to point out what sequence of treatment is more effective trying to find out some guidelines which can be useful in clinical practice. Methods. Retrospective analysis of clinical data of 54 patients with PGL admitted at a University surgical department during 10 years. All the patients underwent neoadjuvant or adjuvant chemotherapy and D2 gastrectomy. Follow-up ranged from 6 to 120 months. Survival was related to: Mushoff's stage of disease, the grade according to the Working Formulation and the sequence of treatment. Statistical analysis was performed by Kaplan-Maier method and the difference between survival curves was compared by log-rank test. Results. Mean postoperative hospital stay was 12 days and morbidity was 18{\%}. Five and 10 years overall survival rates were 70 and 85{\%}. There was a significant difference in survival between patients with high grade PGL and those with intermediate grade (p=0.0188) as well as in those with low grade (p=0.0435). Patients in stages IE-II1E had a significantly longer survival than those in stages IIIE-IVE (p=0.0123). Patients in stages IE-II1E underwent neadjuvant chemotherapy and surgery and survived longer than those in whom surgery preceded chemotherapy (p=0.0293) instead for patients in stages IIIE-IVE neoadjuvant chemotherapy shortened survival (p=0.0403). Conclusions. In personal opinion, in patients in stages IE-II1E chemotherapy should be carried out before surgery, while in those in stages IIIE-IVE the reverse scheme is more effective in achieving longer survival rates.",
keywords = "Chemotherapy, adjuvant, Gastrectomy, Lymphoma, Neoadjuvant chemotherapy, Stomach neoplasms",
author = "Franciosi, {C. M.} and C. Angelini and C. Mussi and P. Sartori and F. Romano and {De Fina}, S. and F. Uggeri",
year = "2001",
language = "Italian",
volume = "56",
pages = "337--343",
journal = "Minerva Chirurgica",
issn = "0026-4733",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Linfoma a localizzazione gastrica. Attualità nel trattamento multidisciplinare

AU - Franciosi, C. M.

AU - Angelini, C.

AU - Mussi, C.

AU - Sartori, P.

AU - Romano, F.

AU - De Fina, S.

AU - Uggeri, F.

PY - 2001

Y1 - 2001

N2 - Background. Primitive gastric lymphoma (PGL) is a rare tumour, and although its incidence is rising it is difficult to state the role of the various therapeutic methods in treating this disease. Aim of this study is to point out what sequence of treatment is more effective trying to find out some guidelines which can be useful in clinical practice. Methods. Retrospective analysis of clinical data of 54 patients with PGL admitted at a University surgical department during 10 years. All the patients underwent neoadjuvant or adjuvant chemotherapy and D2 gastrectomy. Follow-up ranged from 6 to 120 months. Survival was related to: Mushoff's stage of disease, the grade according to the Working Formulation and the sequence of treatment. Statistical analysis was performed by Kaplan-Maier method and the difference between survival curves was compared by log-rank test. Results. Mean postoperative hospital stay was 12 days and morbidity was 18%. Five and 10 years overall survival rates were 70 and 85%. There was a significant difference in survival between patients with high grade PGL and those with intermediate grade (p=0.0188) as well as in those with low grade (p=0.0435). Patients in stages IE-II1E had a significantly longer survival than those in stages IIIE-IVE (p=0.0123). Patients in stages IE-II1E underwent neadjuvant chemotherapy and surgery and survived longer than those in whom surgery preceded chemotherapy (p=0.0293) instead for patients in stages IIIE-IVE neoadjuvant chemotherapy shortened survival (p=0.0403). Conclusions. In personal opinion, in patients in stages IE-II1E chemotherapy should be carried out before surgery, while in those in stages IIIE-IVE the reverse scheme is more effective in achieving longer survival rates.

AB - Background. Primitive gastric lymphoma (PGL) is a rare tumour, and although its incidence is rising it is difficult to state the role of the various therapeutic methods in treating this disease. Aim of this study is to point out what sequence of treatment is more effective trying to find out some guidelines which can be useful in clinical practice. Methods. Retrospective analysis of clinical data of 54 patients with PGL admitted at a University surgical department during 10 years. All the patients underwent neoadjuvant or adjuvant chemotherapy and D2 gastrectomy. Follow-up ranged from 6 to 120 months. Survival was related to: Mushoff's stage of disease, the grade according to the Working Formulation and the sequence of treatment. Statistical analysis was performed by Kaplan-Maier method and the difference between survival curves was compared by log-rank test. Results. Mean postoperative hospital stay was 12 days and morbidity was 18%. Five and 10 years overall survival rates were 70 and 85%. There was a significant difference in survival between patients with high grade PGL and those with intermediate grade (p=0.0188) as well as in those with low grade (p=0.0435). Patients in stages IE-II1E had a significantly longer survival than those in stages IIIE-IVE (p=0.0123). Patients in stages IE-II1E underwent neadjuvant chemotherapy and surgery and survived longer than those in whom surgery preceded chemotherapy (p=0.0293) instead for patients in stages IIIE-IVE neoadjuvant chemotherapy shortened survival (p=0.0403). Conclusions. In personal opinion, in patients in stages IE-II1E chemotherapy should be carried out before surgery, while in those in stages IIIE-IVE the reverse scheme is more effective in achieving longer survival rates.

KW - Chemotherapy, adjuvant

KW - Gastrectomy

KW - Lymphoma

KW - Neoadjuvant chemotherapy

KW - Stomach neoplasms

UR - http://www.scopus.com/inward/record.url?scp=0035432226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035432226&partnerID=8YFLogxK

M3 - Articolo

VL - 56

SP - 337

EP - 343

JO - Minerva Chirurgica

JF - Minerva Chirurgica

SN - 0026-4733

IS - 4

ER -