Several tumour antigens have been molecularly defined during the last few years and three main groups of melanoma-associated antigens have been identified according to their pattern of expression. Despite their wide expression in the Caucasian population, human leukocyte antigen (HLA) class I-presenting molecules, alternate to HLA-A2.1, have received little attention. To further explore the complexity of HLA class I-presented melanoma epitopes, we looked for the existence of other antigens recognized by T cells in HLA-A3.1 and HLAA2.1 restriction. The pattern of recognition identified by HLAA3.1 or HLA-A2.1-restricted T-cell lines and clones indicated the existence of a novel category of antigens represented by proteins expressed by melanomase but not by melanocytes.
|Issue number||SUPPL. 2|
|Publication status||Published - 1997|
- T cells
ASJC Scopus subject areas
- Cancer Research