New tumour-restricted melanoma antigens as defined by cytotoxic T-cell responses

Giorgio Parmiani, Andrea Anichini, Chiara Castelli

Research output: Contribution to journalArticle

Abstract

Several tumour antigens have been molecularly defined during the last few years and three main groups of melanoma-associated antigens have been identified according to their pattern of expression. Despite their wide expression in the Caucasian population, human leukocyte antigen (HLA) class I-presenting molecules, alternate to HLA-A2.1, have received little attention. To further explore the complexity of HLA class I-presented melanoma epitopes, we looked for the existence of other antigens recognized by T cells in HLA-A3.1 and HLAA2.1 restriction. The pattern of recognition identified by HLAA3.1 or HLA-A2.1-restricted T-cell lines and clones indicated the existence of a novel category of antigens represented by proteins expressed by melanomase but not by melanocytes.

Original languageEnglish
JournalMelanoma Research
Volume7
Issue numberSUPPL. 2
Publication statusPublished - 1997

Keywords

  • Antigens
  • Melanoma
  • T cells

ASJC Scopus subject areas

  • Cancer Research
  • Dermatology

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