New universal definition of myocardial infarction

Applicable after complex percutaneous coronary interventions?

Didier Locca, Chiara Bucciarelli-Ducci, Giuseppe Ferrante, Alessio La Manna, Niall G. Keenan, Agata Grasso, Peter Barlis, Francesca Del Furia, Sanjay K. Prasad, Juan Carlos Kaski, Dudley J. Pennell, Carlo Di Mario

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objectives This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury. Background Cardiovascular magnetic resonance accurately assesses infarct size. Baseline C-reactive protein (CRP) and neopterin predict prognosis after stent implantation. Methods Consecutive patients with baseline troponin (Tn) I within normal limits and no LGE in the target vessel underwent baseline and post-PCI CMR. The Tn-I was measured until 24 h after PCI. Serum high-sensitivity CRP and neopterin were assessed before coronary angiography. Results Of 45 patients, 64 (53 to 72) years of age, 33% developed LGE with infarct size of 0.83 g (interquartile range: 0.32 to 1.30 g). A Tn-I elevation >99% upper reference limit (i.e., myocardial necrosis) (median Tn-I: 0.51 μg/l, interquartile range: 0.16 to 1.23) and Tn-I >3× upper reference limit (i.e., type 4a myocardial infarction [MI]) occurred in 58% and 47% patients, respectively. LGE was undetectable in 42% and 43% of patients with periprocedural myocardial necrosis and type 4a MI, respectively. Agreement between LGE and type 4a MI was moderate (kappa = 0.45). The levels of CRP or neopterin did not significantly differ between patients with or without myocardial injury, detected by CMR or according to the new definition (p = NS). Conclusions This study reports the lack of substantial agreement between the new universal definition and CMR for the diagnosis of small-size periprocedural myocardial damage after complex PCI. Baseline levels of CRP or neopterin were not predictive for the development of periprocedural myocardial damage.

Original languageEnglish
Pages (from-to)950-958
Number of pages9
JournalJACC: Cardiovascular Interventions
Volume3
Issue number9
DOIs
Publication statusPublished - Sep 2010

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Percutaneous Coronary Intervention
Troponin I
Gadolinium
Neopterin
Myocardial Infarction
Magnetic Resonance Spectroscopy
C-Reactive Protein
Necrosis
Wounds and Injuries
Coronary Angiography
Stents
Biomarkers
Serum

Keywords

  • C-reactive protein
  • cardiovascular magnetic resonance imaging
  • distal embolization
  • neopterin
  • percutaneous coronary interventions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

New universal definition of myocardial infarction : Applicable after complex percutaneous coronary interventions? / Locca, Didier; Bucciarelli-Ducci, Chiara; Ferrante, Giuseppe; La Manna, Alessio; Keenan, Niall G.; Grasso, Agata; Barlis, Peter; Del Furia, Francesca; Prasad, Sanjay K.; Kaski, Juan Carlos; Pennell, Dudley J.; Di Mario, Carlo.

In: JACC: Cardiovascular Interventions, Vol. 3, No. 9, 09.2010, p. 950-958.

Research output: Contribution to journalArticle

Locca, D, Bucciarelli-Ducci, C, Ferrante, G, La Manna, A, Keenan, NG, Grasso, A, Barlis, P, Del Furia, F, Prasad, SK, Kaski, JC, Pennell, DJ & Di Mario, C 2010, 'New universal definition of myocardial infarction: Applicable after complex percutaneous coronary interventions?', JACC: Cardiovascular Interventions, vol. 3, no. 9, pp. 950-958. https://doi.org/10.1016/j.jcin.2010.06.015
Locca, Didier ; Bucciarelli-Ducci, Chiara ; Ferrante, Giuseppe ; La Manna, Alessio ; Keenan, Niall G. ; Grasso, Agata ; Barlis, Peter ; Del Furia, Francesca ; Prasad, Sanjay K. ; Kaski, Juan Carlos ; Pennell, Dudley J. ; Di Mario, Carlo. / New universal definition of myocardial infarction : Applicable after complex percutaneous coronary interventions?. In: JACC: Cardiovascular Interventions. 2010 ; Vol. 3, No. 9. pp. 950-958.
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abstract = "Objectives This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury. Background Cardiovascular magnetic resonance accurately assesses infarct size. Baseline C-reactive protein (CRP) and neopterin predict prognosis after stent implantation. Methods Consecutive patients with baseline troponin (Tn) I within normal limits and no LGE in the target vessel underwent baseline and post-PCI CMR. The Tn-I was measured until 24 h after PCI. Serum high-sensitivity CRP and neopterin were assessed before coronary angiography. Results Of 45 patients, 64 (53 to 72) years of age, 33{\%} developed LGE with infarct size of 0.83 g (interquartile range: 0.32 to 1.30 g). A Tn-I elevation >99{\%} upper reference limit (i.e., myocardial necrosis) (median Tn-I: 0.51 μg/l, interquartile range: 0.16 to 1.23) and Tn-I >3× upper reference limit (i.e., type 4a myocardial infarction [MI]) occurred in 58{\%} and 47{\%} patients, respectively. LGE was undetectable in 42{\%} and 43{\%} of patients with periprocedural myocardial necrosis and type 4a MI, respectively. Agreement between LGE and type 4a MI was moderate (kappa = 0.45). The levels of CRP or neopterin did not significantly differ between patients with or without myocardial injury, detected by CMR or according to the new definition (p = NS). Conclusions This study reports the lack of substantial agreement between the new universal definition and CMR for the diagnosis of small-size periprocedural myocardial damage after complex PCI. Baseline levels of CRP or neopterin were not predictive for the development of periprocedural myocardial damage.",
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AU - Ferrante, Giuseppe

AU - La Manna, Alessio

AU - Keenan, Niall G.

AU - Grasso, Agata

AU - Barlis, Peter

AU - Del Furia, Francesca

AU - Prasad, Sanjay K.

AU - Kaski, Juan Carlos

AU - Pennell, Dudley J.

AU - Di Mario, Carlo

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N2 - Objectives This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury. Background Cardiovascular magnetic resonance accurately assesses infarct size. Baseline C-reactive protein (CRP) and neopterin predict prognosis after stent implantation. Methods Consecutive patients with baseline troponin (Tn) I within normal limits and no LGE in the target vessel underwent baseline and post-PCI CMR. The Tn-I was measured until 24 h after PCI. Serum high-sensitivity CRP and neopterin were assessed before coronary angiography. Results Of 45 patients, 64 (53 to 72) years of age, 33% developed LGE with infarct size of 0.83 g (interquartile range: 0.32 to 1.30 g). A Tn-I elevation >99% upper reference limit (i.e., myocardial necrosis) (median Tn-I: 0.51 μg/l, interquartile range: 0.16 to 1.23) and Tn-I >3× upper reference limit (i.e., type 4a myocardial infarction [MI]) occurred in 58% and 47% patients, respectively. LGE was undetectable in 42% and 43% of patients with periprocedural myocardial necrosis and type 4a MI, respectively. Agreement between LGE and type 4a MI was moderate (kappa = 0.45). The levels of CRP or neopterin did not significantly differ between patients with or without myocardial injury, detected by CMR or according to the new definition (p = NS). Conclusions This study reports the lack of substantial agreement between the new universal definition and CMR for the diagnosis of small-size periprocedural myocardial damage after complex PCI. Baseline levels of CRP or neopterin were not predictive for the development of periprocedural myocardial damage.

AB - Objectives This study aimed to characterize myocardial infarction after percutaneous coronary intervention (PCI) based on cardiac marker elevation as recommended by the new universal definition and on the detection of late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR). It is also assessed whether baseline inflammatory biomarkers are higher in patients developing myocardial injury. Background Cardiovascular magnetic resonance accurately assesses infarct size. Baseline C-reactive protein (CRP) and neopterin predict prognosis after stent implantation. Methods Consecutive patients with baseline troponin (Tn) I within normal limits and no LGE in the target vessel underwent baseline and post-PCI CMR. The Tn-I was measured until 24 h after PCI. Serum high-sensitivity CRP and neopterin were assessed before coronary angiography. Results Of 45 patients, 64 (53 to 72) years of age, 33% developed LGE with infarct size of 0.83 g (interquartile range: 0.32 to 1.30 g). A Tn-I elevation >99% upper reference limit (i.e., myocardial necrosis) (median Tn-I: 0.51 μg/l, interquartile range: 0.16 to 1.23) and Tn-I >3× upper reference limit (i.e., type 4a myocardial infarction [MI]) occurred in 58% and 47% patients, respectively. LGE was undetectable in 42% and 43% of patients with periprocedural myocardial necrosis and type 4a MI, respectively. Agreement between LGE and type 4a MI was moderate (kappa = 0.45). The levels of CRP or neopterin did not significantly differ between patients with or without myocardial injury, detected by CMR or according to the new definition (p = NS). Conclusions This study reports the lack of substantial agreement between the new universal definition and CMR for the diagnosis of small-size periprocedural myocardial damage after complex PCI. Baseline levels of CRP or neopterin were not predictive for the development of periprocedural myocardial damage.

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KW - distal embolization

KW - neopterin

KW - percutaneous coronary interventions

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