Newly diagnosed ovarian cancer: Which first-line treatment?

Domenica Lorusso, Valentina Ceni, Gennaro Daniele, Vanda Salutari, Antonella Pietragalla, Margherita Muratore, Camilla Nero, Francesca Ciccarone, Giovanni Scambia

Research output: Contribution to journalReview articlepeer-review

Abstract

Poly ADP -Ribose Polymerase (PARP) inhibitors (PARPi) were firstly licensed for maintenance treatment in recurrent, platinum-sensitive, platinum responsive epithelial ovarian cancer patients, harboring or not a BRCA mutation. Three new phase III trials – PAOLA1/ENGOT-OV25, PRIMA/ENGOT-OV26 and VELIA/GOG-3005 – showed that there is a role for PARPi also in first-line setting, as maintenance or in combination with platinum-based chemotherapy. Nevertheless the published trials raised several questions on what is the best treatment according to the molecular and clinical characteristics of the treated patients. This review focuses on the published data in order to inform clinician decision making on what could be the best sequence or combination of treatments for the three molecular defined cohorts of patients emerging in the first line trials (the carriers of a BRCA mutation (BRCAmut), those with a deficiency in homologous recombination system (HRd) and those with a proficient homologous recombination system (HRp)) and put the newly published data in the context of the ovarian cancer treatment landscape.

Original languageEnglish
Article number102111
JournalCancer Treatment Reviews
Volume91
DOIs
Publication statusPublished - Dec 2020

Keywords

  • HRD
  • Maintenance
  • Ovarian cancer
  • PARP inhibitors

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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