Next generation biomarkers for brain injury

Laura D. Serpero, Valentina Bellissima, Micaela Colivicchi, Miriam Sabatini, Alessandro Frigiola, Alberto Ricotti, Valeria Ghiglione, Maria C. Strozzi, Giovanni Li Volti, Fabio Galvano, Diego Gazzolo

Research output: Contribution to journalArticlepeer-review


In perinatal medicine, there is an emerging interest on the potential usefulness of non-invasive brain biochemical monitoring in infants at risk for brain injury. To date, several biomarkers such as neuro-proteins, calcium binding proteins, oxidative stress markers, vasoactive agents, inflammatory mediators, have been investigated. Results showed that hypoxia insult, under different conditions, triggers a biochemical pathophysiological cascade of events leading to brain damage. In this setting, increased biomarkers concentrations in different biological fluids have been found to correlate with the occurrence of brain damage at short-long term both in preterm and term fetuses/newborns. However, before inclusion of any biomarker in guidelines, USA and European institutions have recently stated a panel of criteria that have to be fulfilled. Therefore, the present review offers an overview of the main biomarkers currently studied in perinatal medicine and their progresses according to institutions' criteria.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue numberSUPPL.2
Publication statusPublished - Oct 2013


  • Activin A
  • Brain damage
  • Cardiovascular
  • G-FAP
  • HO-1
  • NSE
  • Oxidative stress
  • S100B

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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