TY - JOUR
T1 - Next generation biomarkers for brain injury
AU - Serpero, Laura D.
AU - Bellissima, Valentina
AU - Colivicchi, Micaela
AU - Sabatini, Miriam
AU - Frigiola, Alessandro
AU - Ricotti, Alberto
AU - Ghiglione, Valeria
AU - Strozzi, Maria C.
AU - Li Volti, Giovanni
AU - Galvano, Fabio
AU - Gazzolo, Diego
PY - 2013/10
Y1 - 2013/10
N2 - In perinatal medicine, there is an emerging interest on the potential usefulness of non-invasive brain biochemical monitoring in infants at risk for brain injury. To date, several biomarkers such as neuro-proteins, calcium binding proteins, oxidative stress markers, vasoactive agents, inflammatory mediators, have been investigated. Results showed that hypoxia insult, under different conditions, triggers a biochemical pathophysiological cascade of events leading to brain damage. In this setting, increased biomarkers concentrations in different biological fluids have been found to correlate with the occurrence of brain damage at short-long term both in preterm and term fetuses/newborns. However, before inclusion of any biomarker in guidelines, USA and European institutions have recently stated a panel of criteria that have to be fulfilled. Therefore, the present review offers an overview of the main biomarkers currently studied in perinatal medicine and their progresses according to institutions' criteria.
AB - In perinatal medicine, there is an emerging interest on the potential usefulness of non-invasive brain biochemical monitoring in infants at risk for brain injury. To date, several biomarkers such as neuro-proteins, calcium binding proteins, oxidative stress markers, vasoactive agents, inflammatory mediators, have been investigated. Results showed that hypoxia insult, under different conditions, triggers a biochemical pathophysiological cascade of events leading to brain damage. In this setting, increased biomarkers concentrations in different biological fluids have been found to correlate with the occurrence of brain damage at short-long term both in preterm and term fetuses/newborns. However, before inclusion of any biomarker in guidelines, USA and European institutions have recently stated a panel of criteria that have to be fulfilled. Therefore, the present review offers an overview of the main biomarkers currently studied in perinatal medicine and their progresses according to institutions' criteria.
KW - Activin A
KW - Brain damage
KW - Cardiovascular
KW - G-FAP
KW - HO-1
KW - NSE
KW - Oxidative stress
KW - S100B
UR - http://www.scopus.com/inward/record.url?scp=84884652315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884652315&partnerID=8YFLogxK
U2 - 10.3109/14767058.2013.829688
DO - 10.3109/14767058.2013.829688
M3 - Article
C2 - 24059552
AN - SCOPUS:84884652315
VL - 26
SP - 44
EP - 49
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - SUPPL.2
ER -