NF-κB/rel-mediated regulation of the neural fate in Drosophila

Savita Ayyar, Daniela Pistillo, Manuel Calleja, Anna Brookfield, Kelly Gittins, Claire Goldstone, Pat Simpson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Two distinct roles are described for Dorsal, Dif and Relish, the three NF-κB/Rel proteins of Drosophila, in the development of the peripheral nervous system. First, these factors regulate transcription of scute during the singling out of sensory organ precursors from clusters of cells expressing the proneural genes achaete and scute. This effect is possibly mediated through binding sites for NF-κB/Rel proteins in a regulatory module of the scute gene required for maintenance of scute expression in precursors as well as repression in cells surrounding precursors. Second, genetic evidence suggests that the receptor Toll-8. Relish, Dif and Dorsal, and the caspase Dredd pathway are active over the entire imaginal disc epithelium, but Toll-8 expression is excluded from sensory organ precursors. Relish promotes rapid turnover of transcripts of the target genes scute and asense through an indirect, post-transcriptional mechanism. We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis.

Original languageEnglish
Article numbere1178
JournalPLoS One
Volume2
Issue number11
DOIs
Publication statusPublished - Nov 14 2007

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sense organs
Drosophila
epithelium
Epithelium
Genes
Imaginal Discs
imaginal discs
peripheral nervous system
neurogenesis
Gene Regulatory Networks
caspases
Neurogenesis
regulatory proteins
Peripheral Nervous System
Caspases
binding sites
Transcription factors
Transcription Factors
genes
transcription factors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ayyar, S., Pistillo, D., Calleja, M., Brookfield, A., Gittins, K., Goldstone, C., & Simpson, P. (2007). NF-κB/rel-mediated regulation of the neural fate in Drosophila. PLoS One, 2(11), [e1178]. https://doi.org/10.1371/journal.pone.0001178

NF-κB/rel-mediated regulation of the neural fate in Drosophila. / Ayyar, Savita; Pistillo, Daniela; Calleja, Manuel; Brookfield, Anna; Gittins, Kelly; Goldstone, Claire; Simpson, Pat.

In: PLoS One, Vol. 2, No. 11, e1178, 14.11.2007.

Research output: Contribution to journalArticle

Ayyar, S, Pistillo, D, Calleja, M, Brookfield, A, Gittins, K, Goldstone, C & Simpson, P 2007, 'NF-κB/rel-mediated regulation of the neural fate in Drosophila', PLoS One, vol. 2, no. 11, e1178. https://doi.org/10.1371/journal.pone.0001178
Ayyar S, Pistillo D, Calleja M, Brookfield A, Gittins K, Goldstone C et al. NF-κB/rel-mediated regulation of the neural fate in Drosophila. PLoS One. 2007 Nov 14;2(11). e1178. https://doi.org/10.1371/journal.pone.0001178
Ayyar, Savita ; Pistillo, Daniela ; Calleja, Manuel ; Brookfield, Anna ; Gittins, Kelly ; Goldstone, Claire ; Simpson, Pat. / NF-κB/rel-mediated regulation of the neural fate in Drosophila. In: PLoS One. 2007 ; Vol. 2, No. 11.
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