Parasonnie e crisi frontali notturne: Un disturbo dell'arousal quale meccanismo patogenetico comune?

Translated title of the contribution: NFLE and parasomnias: Different sleep disturbances related by a common disorder of arousal?

F. Bisulli, I. Naldi, L. Licchetta, S. Musho Ilbeh, L. Vignatelli, J. E. Fares, F. Pittau, F. Provini, P. Montagna, P. Tinuper

Research output: Contribution to journalArticle


To verify whether patients with Nocturnal Frontal Lose Epilepsy (NFLE) and their relatives have a higher frequency of parasomnias, in particular arousal disorders, and to shed light on the still unknown physiopathological mechanisms underlying NFLE, 458 individuals were interviewed: 33 patients with NFLE (males/females: 18/15), 200 relatives of probands, 231 control subjects and 194 relatives of controls. The following parasomnias were more frequent in the NFLE group: Probands vs controls: bruxism (p <0.05) and arousal disorders such as sleep walking and sleep terror. Proband relatives vs control relatives: arousal disorders and nightmares (p <0.001). We confirmed the original hypothesis of a higher frequency of arousal disorders in patients with NFLE and their relatives suggesting a possible common physiopathological mechanism. The study disclosed also two "unexpected" findings: a higher frequency of bruxism in NFLE patients and nightmares in their relatives.

Original languageItalian
Pages (from-to)105-106
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number136-137
Publication statusPublished - May 2008


ASJC Scopus subject areas

  • Clinical Neurology

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