To verify whether patients with Nocturnal Frontal Lose Epilepsy (NFLE) and their relatives have a higher frequency of parasomnias, in particular arousal disorders, and to shed light on the still unknown physiopathological mechanisms underlying NFLE, 458 individuals were interviewed: 33 patients with NFLE (males/females: 18/15), 200 relatives of probands, 231 control subjects and 194 relatives of controls. The following parasomnias were more frequent in the NFLE group: Probands vs controls: bruxism (p <0.05) and arousal disorders such as sleep walking and sleep terror. Proband relatives vs control relatives: arousal disorders and nightmares (p <0.001). We confirmed the original hypothesis of a higher frequency of arousal disorders in patients with NFLE and their relatives suggesting a possible common physiopathological mechanism. The study disclosed also two "unexpected" findings: a higher frequency of bruxism in NFLE patients and nightmares in their relatives.
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - May 2008|
ASJC Scopus subject areas
- Clinical Neurology