N(G)-methyl-L-arginine increases the hyperthermic effects of prostaglandin E1

M. Monda, A. Sullo, E. De Luca

Research output: Contribution to journalArticlepeer-review

Abstract

The sympathetic firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (T(IBAT) and T(C)) were monitored in urethane-anaesthetized male Sprague-Dawley rats. These variables were measured for a period of 40 min before (baseline values) and 40 min after a 2 mg N(G)methyl-L-arginine (NMA) injection plus an intracerebroventricular administration of 500 ng prostaglandin E1 (PGE1) into a lateral cerebral ventricle. No drug was injected in control rats. The results show that NMA enhances the increases in firing rate, T(IBAT) and T(C) induced by PGE1. These findings indicate that an inhibitor of nitric oxide synthesis, such as NMA, increases the sympathetic and thermogenic responses to injection of PGE1.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Physiology Paris
Volume90
Issue number2
DOIs
Publication statusPublished - 1996

Keywords

  • Brown adipose tissue
  • Hyperthermia
  • N(G)-methyl-L-arginine
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology (medical)
  • Neuroscience(all)

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