Abstract
Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of αD11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.
Original language | English |
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Pages (from-to) | 295-297 |
Number of pages | 3 |
Journal | Developmental Brain Research |
Volume | 101 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Jul 1997 |
Keywords
- Antibody
- CA3
- Development
- Hippocampus
- Long-term depression
- Nerve growth factor
- Plasticity
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience