NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

Francesca Ruberti; Nicola Berretta; Antonino Cattaneo; Enrico Cherubini

doi:10.1016/S0165-3806(97)00082-5

NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

Francesca Ruberti, Nicola Berretta, Antonino Cattaneo, Enrico Cherubini

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of αD11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.

Original language	English
Pages (from-to)	295-297
Number of pages	3
Journal	Developmental Brain Research
Volume	101
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-3806(97)00082-5
Publication status	Published - Jul 1997

Keywords

Antibody
CA3
Development
Hippocampus
Long-term depression
Nerve growth factor
Plasticity

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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title = "NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus",

abstract = "Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of αD11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.",

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author = "Francesca Ruberti and Nicola Berretta and Antonino Cattaneo and Enrico Cherubini",

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AU - Ruberti, Francesca

AU - Berretta, Nicola

AU - Cattaneo, Antonino

AU - Cherubini, Enrico

PY - 1997/7

Y1 - 1997/7

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AB - Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of αD11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.

KW - Antibody

KW - CA3

KW - Development

KW - Hippocampus

KW - Long-term depression

KW - Nerve growth factor

KW - Plasticity

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NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

Abstract

Keywords

ASJC Scopus subject areas

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