NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

Francesca Ruberti, Nicola Berretta, Antonino Cattaneo, Enrico Cherubini

Research output: Contribution to journalArticlepeer-review

Abstract

Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of αD11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.

Original languageEnglish
Pages (from-to)295-297
Number of pages3
JournalDevelopmental Brain Research
Volume101
Issue number1-2
DOIs
Publication statusPublished - Jul 1997

Keywords

  • Antibody
  • CA3
  • Development
  • Hippocampus
  • Long-term depression
  • Nerve growth factor
  • Plasticity

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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