Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas

Antonio Caputi; Monica Di Luca; Lucia Pastorino; Francesca Colciaghi; Nicola Carfagna; Eric Wong; Claes Post; Flaminio Cattabeni

doi:10.1002/(SICI)1520-6769(199811/12)23:3<159::AID-NRC4>3.0.CO;2-#

Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas

Antonio Caputi, Monica Di Luca, Lucia Pastorino, Francesca Colciaghi, Nicola Carfagna, Eric Wong, Claes Post, Flaminio Cattabeni

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ⁺⁺-dependent PKC isozymes α and β, but not of the Ca ⁺⁺ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.

Original language	English
Pages (from-to)	159-167
Number of pages	9
Journal	Neuroscience Research Communications
Volume	23
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1520-6769(199811/12)23:3<159::AID-NRC4>3.0.CO;2-#
Publication status	Published - Nov 1998

Keywords

Cognitive enhancers
Protein kinase C
Rat
Synaptic plasticity
Synaptosomes

ASJC Scopus subject areas

Neuroscience(all)

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10.1002/(SICI)1520-6769(199811/12)23:3<159::AID-NRC4>3.0.CO;2-#

Cite this

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title = "Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas",

abstract = "In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.",

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author = "Antonio Caputi and {Di Luca}, Monica and Lucia Pastorino and Francesca Colciaghi and Nicola Carfagna and Eric Wong and Claes Post and Flaminio Cattabeni",

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T1 - Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas

AU - Caputi, Antonio

AU - Di Luca, Monica

AU - Pastorino, Lucia

AU - Colciaghi, Francesca

AU - Carfagna, Nicola

AU - Wong, Eric

AU - Post, Claes

AU - Cattabeni, Flaminio

PY - 1998/11

Y1 - 1998/11

N2 - In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.

AB - In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.

KW - Cognitive enhancers

KW - Protein kinase C

KW - Rat

KW - Synaptic plasticity

KW - Synaptosomes

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Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas

Abstract

Keywords

ASJC Scopus subject areas

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