Abstract
In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 159-167 |
| Number of pages | 9 |
| Journal | Neuroscience Research Communications |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Nov 1998 |
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Keywords
- Cognitive enhancers
- Protein kinase C
- Rat
- Synaptic plasticity
- Synaptosomes
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas. / Caputi, Antonio; Di Luca, Monica; Pastorino, Lucia; Colciaghi, Francesca; Carfagna, Nicola; Wong, Eric; Post, Claes; Cattabeni, Flaminio.
In: Neuroscience Research Communications, Vol. 23, No. 3, 11.1998, p. 159-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nicergoline and its metabolite induce translocation of PKC isoforms in selective rat brain areas
AU - Caputi, Antonio
AU - Di Luca, Monica
AU - Pastorino, Lucia
AU - Colciaghi, Francesca
AU - Carfagna, Nicola
AU - Wong, Eric
AU - Post, Claes
AU - Cattabeni, Flaminio
PY - 1998/11
Y1 - 1998/11
N2 - In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.
AB - In view of the important role of PKC in synaptic plasticity we have investigated the ability of Nicergoline to affect translocation of PKC isoforms in synaptosomes obtained from distinct brain areas. In isolated synaptosomes obtained from rat hippocampus and striatum, nicergoline was able to induce in a concentration dependent fashion the translocation of the Ca ++-dependent PKC isozymes α and β, but not of the Ca ++ independent ε. The effect is confined to hippocampus and striatum. MDL, the major nicergoline metabolite, is more potent in modulating PKC activity in all the brain areas evaluated. These data suggest that PKC may represent an pharmacological target at presynaptic level for nicergoline and its derivatives.
KW - Cognitive enhancers
KW - Protein kinase C
KW - Rat
KW - Synaptic plasticity
KW - Synaptosomes
UR - http://www.scopus.com/inward/record.url?scp=0032436578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032436578&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1520-6769(199811/12)23:3<159::AID-NRC4>3.0.CO;2-#
DO - 10.1002/(SICI)1520-6769(199811/12)23:3<159::AID-NRC4>3.0.CO;2-#
M3 - Article
VL - 23
SP - 159
EP - 167
JO - Neuroscience Research Communications
JF - Neuroscience Research Communications
SN - 0893-6609
IS - 3
ER -