Nickel earlobe dermatitis and clinical non-relevance of the oral exposure

F. Di Berardino, D. Alpini, A. Cesarani

Research output: Contribution to journalArticlepeer-review


Objective: Nickel is the most common cause of allergic contact dermatitis (ACD). Because nickel restriction is commonly imposed on many patients with the only earlobe ACD to nickel hypersensitivity, the aim of this study was to identify the role of occasional and extended oral nickel exposure in these patients. Design: This is a case-control study. Subjects: Thirty-four outpatients, previously diagnosed as monosensitized to nickel, suffering from earlobe dermatitis were enrolled; 11 of them showed active dermatitis. The control group consisted of six healthy (non-nickel-sensitive) subjects. Interventions: High oral nickel challenge (20 mg) and protracted oral challenge (1 mg once a day). Observation period: 6 weeks. Results: Clinical earlobe lesions were not affected by a high oral nickel intake nor by a protracted oral challenge. Conclusions: Dietary nickel restriction seems to be useless in patients with earlobe ACD due to nickel hypersensitivity.

Original languageEnglish
Pages (from-to)1215-1217
Number of pages3
JournalJournal of the European Academy of Dermatology and Venereology
Issue number10
Publication statusPublished - Oct 2008


  • ACD
  • Earlobe dermatitis
  • Nickel
  • Nickel oral intake

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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