Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma

Davide Sartini, Andrea Santarelli, Valentina Rossi, Gaia Goteri, Corrado Rubini, Domenico Ciavarella, Lorenzo Lo Muzio, Monica Emanuelli

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by semi-quantitative RT-PCR and quantitative real-time PCR in tumor and matched adjacent healthy tissue. Interestingly, NNMT was upregulated in most of the favorable OSCCs, while no marked NNMT expression alterations between tumor and normal mucosa were detected in most of the unfavorable OSCCs, Western blot and immunohistochemical analyses also were performed and the relationship between tumor characteristics and NNMT levels in OSCC were studied to evaluate the effectiveness of NNMT as a prognostic marker in the squamous cell carcinoma of the oral cavity. In summary, the present study suggests that NNMT may have potential as a biomarker and a therapeutic target for OSCC.

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalMolecular medicine (Cambridge, Mass.)
Volume13
Issue number7-8
DOIs
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Genetics

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