Nicotine dependence may link the 15q25 locus to lung cancer risk

Antonella Galvan, Tommaso A. Dragani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The nicotinic 15q25 locus has been implicated in lung cancer risk, with an odds ratio of ~ 1.3. The same locus is associated with nicotine dependence due to cigarette smoking and with smokingassociated chronic obstructive pulmonary disease, which is a risk factor for lung cancer. Our meta-analysis of reported studies shows that this locus was not associated with lung cancer risk in >1000 never-smoker cases and >1800 controls. Review of exposure-response data for lung cancer risk showed that less than a half-cigarette per day may confer the same risk of lung cancer as that conferred by the 15q25 locus. Given the lack of effect in never-smokers and the known common and variable underreporting of smoking habit in studies on smoking-associated diseases, we cannot exclude that the association between the 15q25 locus and lung cancer risk is indirect, deriving from association of the same locus with smoking habit. Since nicotine is not carcinogenic, available data do not provide plausibility of the association between the nicotinic 15q25 locus and lung cancer pathogenesis. Thus, a direct link between the 15q25 locus and lung cancer risk has yet to be established.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalCarcinogenesis
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Tobacco Use Disorder
Lung Neoplasms
Smoking
Habits
Nicotine
Tobacco Products
Chronic Obstructive Pulmonary Disease
Meta-Analysis
Odds Ratio

ASJC Scopus subject areas

  • Cancer Research

Cite this

Nicotine dependence may link the 15q25 locus to lung cancer risk. / Galvan, Antonella; Dragani, Tommaso A.

In: Carcinogenesis, Vol. 31, No. 3, 03.2010, p. 331-333.

Research output: Contribution to journalArticle

@article{72168fdbf5e3452a90816773c8039284,
title = "Nicotine dependence may link the 15q25 locus to lung cancer risk",
abstract = "The nicotinic 15q25 locus has been implicated in lung cancer risk, with an odds ratio of ~ 1.3. The same locus is associated with nicotine dependence due to cigarette smoking and with smokingassociated chronic obstructive pulmonary disease, which is a risk factor for lung cancer. Our meta-analysis of reported studies shows that this locus was not associated with lung cancer risk in >1000 never-smoker cases and >1800 controls. Review of exposure-response data for lung cancer risk showed that less than a half-cigarette per day may confer the same risk of lung cancer as that conferred by the 15q25 locus. Given the lack of effect in never-smokers and the known common and variable underreporting of smoking habit in studies on smoking-associated diseases, we cannot exclude that the association between the 15q25 locus and lung cancer risk is indirect, deriving from association of the same locus with smoking habit. Since nicotine is not carcinogenic, available data do not provide plausibility of the association between the nicotinic 15q25 locus and lung cancer pathogenesis. Thus, a direct link between the 15q25 locus and lung cancer risk has yet to be established.",
author = "Antonella Galvan and Dragani, {Tommaso A.}",
year = "2010",
month = "3",
doi = "10.1093/carcin/bgp282",
language = "English",
volume = "31",
pages = "331--333",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Nicotine dependence may link the 15q25 locus to lung cancer risk

AU - Galvan, Antonella

AU - Dragani, Tommaso A.

PY - 2010/3

Y1 - 2010/3

N2 - The nicotinic 15q25 locus has been implicated in lung cancer risk, with an odds ratio of ~ 1.3. The same locus is associated with nicotine dependence due to cigarette smoking and with smokingassociated chronic obstructive pulmonary disease, which is a risk factor for lung cancer. Our meta-analysis of reported studies shows that this locus was not associated with lung cancer risk in >1000 never-smoker cases and >1800 controls. Review of exposure-response data for lung cancer risk showed that less than a half-cigarette per day may confer the same risk of lung cancer as that conferred by the 15q25 locus. Given the lack of effect in never-smokers and the known common and variable underreporting of smoking habit in studies on smoking-associated diseases, we cannot exclude that the association between the 15q25 locus and lung cancer risk is indirect, deriving from association of the same locus with smoking habit. Since nicotine is not carcinogenic, available data do not provide plausibility of the association between the nicotinic 15q25 locus and lung cancer pathogenesis. Thus, a direct link between the 15q25 locus and lung cancer risk has yet to be established.

AB - The nicotinic 15q25 locus has been implicated in lung cancer risk, with an odds ratio of ~ 1.3. The same locus is associated with nicotine dependence due to cigarette smoking and with smokingassociated chronic obstructive pulmonary disease, which is a risk factor for lung cancer. Our meta-analysis of reported studies shows that this locus was not associated with lung cancer risk in >1000 never-smoker cases and >1800 controls. Review of exposure-response data for lung cancer risk showed that less than a half-cigarette per day may confer the same risk of lung cancer as that conferred by the 15q25 locus. Given the lack of effect in never-smokers and the known common and variable underreporting of smoking habit in studies on smoking-associated diseases, we cannot exclude that the association between the 15q25 locus and lung cancer risk is indirect, deriving from association of the same locus with smoking habit. Since nicotine is not carcinogenic, available data do not provide plausibility of the association between the nicotinic 15q25 locus and lung cancer pathogenesis. Thus, a direct link between the 15q25 locus and lung cancer risk has yet to be established.

UR - http://www.scopus.com/inward/record.url?scp=77950914847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950914847&partnerID=8YFLogxK

U2 - 10.1093/carcin/bgp282

DO - 10.1093/carcin/bgp282

M3 - Article

C2 - 19910382

AN - SCOPUS:77950914847

VL - 31

SP - 331

EP - 333

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 3

ER -