Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease

Ioannis Ugo Isaias, Jörg Spiegel, Joachim Brumberg, Kelly P. Cosgrove, Giorgio Marotta, Naoya Oishi, Takahiro Higuchi, Sebastian Küsters, Markus Schiller, Ulrich Dillmann, Christopher H. van Dyck, Andreas Buck, Ken Herrmann, Susanne Schloegl, Jens Volkmann, Michael Lassmann, Klaus Fassbender, Reinhard Lorenz, Samuel Samnick

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (

Original languageEnglish
Article numberArticle 213
JournalFrontiers in Aging Neuroscience
Volume6
Issue numberAUG
DOIs
Publication statusPublished - 2014

Fingerprint

Nicotinic Receptors
Parkinson Disease
Single-Photon Emission-Computed Tomography
Healthy Volunteers
Brain
5-iodo-3-(2-azetidinylmethoxy)pyridine

Keywords

  • 5IA-SPECT
  • Cognitive decline
  • Dopamine acetylcholine
  • Nicotinic receptors
  • Parkinson disease

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

Cite this

Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease. / Isaias, Ioannis Ugo; Spiegel, Jörg; Brumberg, Joachim; Cosgrove, Kelly P.; Marotta, Giorgio; Oishi, Naoya; Higuchi, Takahiro; Küsters, Sebastian; Schiller, Markus; Dillmann, Ulrich; van Dyck, Christopher H.; Buck, Andreas; Herrmann, Ken; Schloegl, Susanne; Volkmann, Jens; Lassmann, Michael; Fassbender, Klaus; Lorenz, Reinhard; Samnick, Samuel.

In: Frontiers in Aging Neuroscience, Vol. 6, No. AUG, Article 213, 2014.

Research output: Contribution to journalArticle

Isaias, IU, Spiegel, J, Brumberg, J, Cosgrove, KP, Marotta, G, Oishi, N, Higuchi, T, Küsters, S, Schiller, M, Dillmann, U, van Dyck, CH, Buck, A, Herrmann, K, Schloegl, S, Volkmann, J, Lassmann, M, Fassbender, K, Lorenz, R & Samnick, S 2014, 'Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease', Frontiers in Aging Neuroscience, vol. 6, no. AUG, Article 213. https://doi.org/10.3389/fnagi.2014.00213
Isaias, Ioannis Ugo ; Spiegel, Jörg ; Brumberg, Joachim ; Cosgrove, Kelly P. ; Marotta, Giorgio ; Oishi, Naoya ; Higuchi, Takahiro ; Küsters, Sebastian ; Schiller, Markus ; Dillmann, Ulrich ; van Dyck, Christopher H. ; Buck, Andreas ; Herrmann, Ken ; Schloegl, Susanne ; Volkmann, Jens ; Lassmann, Michael ; Fassbender, Klaus ; Lorenz, Reinhard ; Samnick, Samuel. / Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease. In: Frontiers in Aging Neuroscience. 2014 ; Vol. 6, No. AUG.
@article{95587726f271455b8529d46200901e4f,
title = "Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease",
abstract = "We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (",
keywords = "5IA-SPECT, Cognitive decline, Dopamine acetylcholine, Nicotinic receptors, Parkinson disease",
author = "Isaias, {Ioannis Ugo} and J{\"o}rg Spiegel and Joachim Brumberg and Cosgrove, {Kelly P.} and Giorgio Marotta and Naoya Oishi and Takahiro Higuchi and Sebastian K{\"u}sters and Markus Schiller and Ulrich Dillmann and {van Dyck}, {Christopher H.} and Andreas Buck and Ken Herrmann and Susanne Schloegl and Jens Volkmann and Michael Lassmann and Klaus Fassbender and Reinhard Lorenz and Samuel Samnick",
year = "2014",
doi = "10.3389/fnagi.2014.00213",
language = "English",
volume = "6",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
number = "AUG",

}

TY - JOUR

T1 - Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease

AU - Isaias, Ioannis Ugo

AU - Spiegel, Jörg

AU - Brumberg, Joachim

AU - Cosgrove, Kelly P.

AU - Marotta, Giorgio

AU - Oishi, Naoya

AU - Higuchi, Takahiro

AU - Küsters, Sebastian

AU - Schiller, Markus

AU - Dillmann, Ulrich

AU - van Dyck, Christopher H.

AU - Buck, Andreas

AU - Herrmann, Ken

AU - Schloegl, Susanne

AU - Volkmann, Jens

AU - Lassmann, Michael

AU - Fassbender, Klaus

AU - Lorenz, Reinhard

AU - Samnick, Samuel

PY - 2014

Y1 - 2014

N2 - We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (

AB - We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (

KW - 5IA-SPECT

KW - Cognitive decline

KW - Dopamine acetylcholine

KW - Nicotinic receptors

KW - Parkinson disease

UR - http://www.scopus.com/inward/record.url?scp=84906282027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906282027&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2014.00213

DO - 10.3389/fnagi.2014.00213

M3 - Article

VL - 6

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - AUG

M1 - Article 213

ER -