Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease

Ioannis Ugo Isaias, Jörg Spiegel, Joachim Brumberg, Kelly P. Cosgrove, Giorgio Marotta, Naoya Oishi, Takahiro Higuchi, Sebastian Küsters, Markus Schiller, Ulrich Dillmann, Christopher H. van Dyck, Andreas Buck, Ken Herrmann, Susanne Schloegl, Jens Volkmann, Michael Lassmann, Klaus Fassbender, Reinhard Lorenz, Samuel Samnick

Research output: Contribution to journalArticle

Abstract

We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([123I]5IA). Patients were selected according to several criteria, including short duration of motor signs (

Original languageEnglish
Article numberArticle 213
JournalFrontiers in Aging Neuroscience
Volume6
Issue numberAUG
DOIs
Publication statusPublished - 2014

Keywords

  • 5IA-SPECT
  • Cognitive decline
  • Dopamine acetylcholine
  • Nicotinic receptors
  • Parkinson disease

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

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  • Cite this

    Isaias, I. U., Spiegel, J., Brumberg, J., Cosgrove, K. P., Marotta, G., Oishi, N., Higuchi, T., Küsters, S., Schiller, M., Dillmann, U., van Dyck, C. H., Buck, A., Herrmann, K., Schloegl, S., Volkmann, J., Lassmann, M., Fassbender, K., Lorenz, R., & Samnick, S. (2014). Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease. Frontiers in Aging Neuroscience, 6(AUG), [Article 213]. https://doi.org/10.3389/fnagi.2014.00213