Oral (17 cases) or sublingual (9 cases) administration of nifedipine (10 mg), a new coronary dilator, induced a prompt and large pressure reduction in patients with severe primary hypertension. Pressure started to fall within 20 and 5 min after oral and sublingual administration, respectively, and reached the lowest levels in the next 10 min. Maximal mean arterial pressure reduction averaged 36 mm Hg; 120 min after the drug, mean arterial pressure was diminished by 19.5% of control. The hypotension was mediated through diminished peripheral resistance associated with rise of cardiac output and pulse rate. Nifedipine was also administered sublingually in 3 cases with hypertensive encephalopathy and acute left ventricular failure with average systemic and pulmonary arterial pressures from 307 164 and 91 55 mm Hg, respectively, which fell to 237 115 and 68 35 mm Hg 15 min after 10 mg of the drug, and were further reduced to 176 89 and to 47 19 mm Hg by an additional 10 mg.
|Number of pages||5|
|Journal||Clinical Pharmacology and Therapeutics|
|Issue number||5 PART 1|
|Publication status||Published - Nov 1977|
ASJC Scopus subject areas
- Pharmacology (medical)