Nifedipine and telmisartan for the treatment of hypertension: The TALENT study

Giuseppe Derosa, Pamela Maffioli

Research output: Contribution to journalArticlepeer-review


A combination of two drugs as initial treatment in patients with a high or very high cardiovascular risk profile is recommended. Nifedipine extended release (GITS) is a calcium-channel antagonist known to be metabolically neutral, to mildly slow the development of atherosclerosis in hypertensive subjects and to significantly decrease cardiovascular risk in diabetic patients. Telmisartan is highly selective for the angiotensin receptor 1, it gives a greater improvement in glycemic and lipid control compared with irbesartan, and it proved its superiority in improving insulin sensitivity compared with eprosartan. The TALENT study was aimed to determine whether combining low-dose nifedipine GITS at and telmisartan reduced ambulatory and clinic blood pressure more than the two components in monotherapy in hypertensive patients at high cardiovascular risk. The study shows that combination treatment with nifedipine GITS and telmisartan provides a greater and earlier blood pressure reduction than the combination components in monotherapy.

Original languageEnglish
Pages (from-to)1499-1503
Number of pages5
JournalExpert Review of Cardiovascular Therapy
Issue number12
Publication statusPublished - Dec 2011


  • adverse events
  • blood pressure
  • combination treatment
  • nifedipine
  • telmisartan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine


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