Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System

Lorenzo Norsa, Laura Zazzeron, Marialaura Cuomo, Laura Claut, Anna Marta Clotilde Bulfamante, Arianna Biffi, Carla Colombo

Research output: Contribution to journalArticle

Abstract

Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut-liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A.

Original languageEnglish
Article numberE1876
JournalNutrients
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 13 2019

    Fingerprint

Keywords

  • cystic fibrosis
  • short bowel syndrome
  • vitamin A deficiency

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this