TY - JOUR
T1 - Nighttime blood pressure and new-onset left ventricular hypertrophy
T2 - Findings from the Pamela population
AU - Cuspidi, Cesare
AU - Facchetti, Rita
AU - Bombelli, Michele
AU - Sala, Carla
AU - Negri, Francesca
AU - Grassi, Guido
AU - Mancia, Giuseppe
PY - 2013/7
Y1 - 2013/7
N2 - The relationship between circadian blood pressure (BP) variations and the extent of subclinical cardiac organ damage is still debated. In a general population, we investigated the association of night-to-day BP fall, as well as nocturnal BP level (mean and lowest values), with left ventricular (LV) hypertrophy and the value of both BP parameters in predicting new-onset LV hypertrophy. Office BP, 24-hour ambulatory BP values, and laboratory investigations were assessed on entry in 1682 subjects (50.2% men; mean age, 50.2±13.7 years) of the Pressioni Arteriose Monitorate E Loro Associazioni. Echocardiographic LV mass was measured at the initial evaluation and 10 years later. Multiple regression analyses, including daytime systolic BP (SBP), age, sex, and body mass index, showed that the lowest SBP level and the extent of nocturnal SBP decline were independently related to baseline LV mass. After adjustment for several confounders, both mean nocturnal SBP (relative risk for each 10-mm Hg increase in SBP, 1.15; 95% confidence interval, 1.01-1.23; P
AB - The relationship between circadian blood pressure (BP) variations and the extent of subclinical cardiac organ damage is still debated. In a general population, we investigated the association of night-to-day BP fall, as well as nocturnal BP level (mean and lowest values), with left ventricular (LV) hypertrophy and the value of both BP parameters in predicting new-onset LV hypertrophy. Office BP, 24-hour ambulatory BP values, and laboratory investigations were assessed on entry in 1682 subjects (50.2% men; mean age, 50.2±13.7 years) of the Pressioni Arteriose Monitorate E Loro Associazioni. Echocardiographic LV mass was measured at the initial evaluation and 10 years later. Multiple regression analyses, including daytime systolic BP (SBP), age, sex, and body mass index, showed that the lowest SBP level and the extent of nocturnal SBP decline were independently related to baseline LV mass. After adjustment for several confounders, both mean nocturnal SBP (relative risk for each 10-mm Hg increase in SBP, 1.15; 95% confidence interval, 1.01-1.23; P
KW - left ventricular hypertrophy
KW - nighttime blood pressure
KW - nocturnal blood pressure fall
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U2 - 10.1161/HYPERTENSIONAHA.111.00682
DO - 10.1161/HYPERTENSIONAHA.111.00682
M3 - Article
C2 - 23690347
AN - SCOPUS:84880716339
VL - 62
SP - 78
EP - 84
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 1
ER -