Nighttime blood pressure and new-onset left ventricular hypertrophy: Findings from the Pamela population

Cesare Cuspidi, Rita Facchetti, Michele Bombelli, Carla Sala, Francesca Negri, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


The relationship between circadian blood pressure (BP) variations and the extent of subclinical cardiac organ damage is still debated. In a general population, we investigated the association of night-to-day BP fall, as well as nocturnal BP level (mean and lowest values), with left ventricular (LV) hypertrophy and the value of both BP parameters in predicting new-onset LV hypertrophy. Office BP, 24-hour ambulatory BP values, and laboratory investigations were assessed on entry in 1682 subjects (50.2% men; mean age, 50.2±13.7 years) of the Pressioni Arteriose Monitorate E Loro Associazioni. Echocardiographic LV mass was measured at the initial evaluation and 10 years later. Multiple regression analyses, including daytime systolic BP (SBP), age, sex, and body mass index, showed that the lowest SBP level and the extent of nocturnal SBP decline were independently related to baseline LV mass. After adjustment for several confounders, both mean nocturnal SBP (relative risk for each 10-mm Hg increase in SBP, 1.15; 95% confidence interval, 1.01-1.23; P

Original languageEnglish
Pages (from-to)78-84
Number of pages7
Issue number1
Publication statusPublished - Jul 2013


  • left ventricular hypertrophy
  • nighttime blood pressure
  • nocturnal blood pressure fall

ASJC Scopus subject areas

  • Internal Medicine


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