Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI

Daniela Frosini, Roberto Ceravolo, Michela Tosetti, Ubaldo Bonuccelli, Mirco Cosottini

Research output: Contribution to journalArticle

Abstract

Ten healthy subjects (HS) and 15 patients with atypical parkinsonisms underwent 7-T susceptibility-weighted-imaging MR to evaluate substantia nigra (SN). All HS were judged “normal”. Twelve out of 15 patients exhibited bilateral abnormal SN while three patients with corticobasal degeneration (CBD) showed bilateral normal aspect of SN. Anatomical changes of SN at 7 T occur in multiple system atrophy and progressive supranuclear palsy as previously reported in Parkinson’s disease. Preserved SN in CBD confirms the pathological heterogeneity of this disease.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalJournal of Neural Transmission
Volume123
Issue number5
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Corticobasal degeneration
  • Magnetic resonance imaging
  • Multiple system atrophy
  • Parkinson’s disease/parkinsonism
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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