Nigro-caudate dopaminergic deafferentation: A marker of REM sleep behavior disorder?

Dario Arnaldi, Fabrizio De Carli, Agnese Picco, Michela Ferrara, Jennifer Accardo, Irene Bossert, Francesco Famà, Nicola Girtler, Silvia Morbelli, Gianmario Sambuceti, Flavio Nobili

Research output: Contribution to journalArticle

Abstract

Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [123I]-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD-) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter-single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different (p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD to PD-RBD- and PD-RBD+ groups while caudate SBR were higher in PD-RBD- group than in PD-RBD+ and even than in iRBD group. Motor impairment was more severe in PD patients with RBD than in those without RBD. Our data suggest that a more severe nigro-caudate dopaminergic deafferentation is related to RBD, both in its idiopathic form and in PD patients.

Original languageEnglish
Pages (from-to)3300-3305
Number of pages6
JournalNeurobiology of Aging
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

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Keywords

  • Parkinson's disease
  • REM sleep behavior disorder
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Arnaldi, D., De Carli, F., Picco, A., Ferrara, M., Accardo, J., Bossert, I., Famà, F., Girtler, N., Morbelli, S., Sambuceti, G., & Nobili, F. (2015). Nigro-caudate dopaminergic deafferentation: A marker of REM sleep behavior disorder? Neurobiology of Aging, 36(12), 3300-3305. https://doi.org/10.1016/j.neurobiolaging.2015.08.025