Niosomes as candidate bioconjugates for imaging and pH-sensitive drug delivery nanocarriers for rare pediatric tumors

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2 Citations (Scopus)

Abstract

Niosomes are non-ionic surfactant vesicles similar to liposomes in structure and function. Novel pH-sensitive niosomes have been reported to enter efficiently and rapidly into hepatoblastoma cells and deliver their cargo. The different surface functionalization of surfactant molecules allowed us to obtain niosomes able to enter efficiently into several tumor cells. This "targeting" property was obtained without the use of large molecules (e.g., antibodies), but only through chemical modifications of surface head groups. Hopefully, the further incorporation of contrast agents or other reported dyes into the niosomes' inner compartment or conjugated to surfactant molecules may produce novel bioconjugates for imaging applications and powerful multifunctional nanocarriers for drug delivery into rare pediatric tumors.

Original languageEnglish
Pages (from-to)22-24
Number of pages3
JournalJournal of Drug Delivery Science and Technology
Volume23
Issue number1
Publication statusPublished - Jan 2013

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Liposomes
Pediatrics
Surface-Active Agents
Pharmaceutical Preparations
Neoplasms
Hepatoblastoma
Contrast Media
Coloring Agents
Head
Antibodies

Keywords

  • Multifunctional vectors
  • Niosomes
  • Non-ionic surfactant vesicles
  • Rare pediatric tumors
  • Tween 20

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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