Abstract
Background: Nipple sparing mastectomy is deemed surgically and oncologically safe based on a long lasting literature data from reviews of single institution series. This study aims at evaluating surgical and oncological outcomes of NSM on a large multi-institutional scale, by means of the Italian National registry. Methods: In July 2011 a panel of Italian specialists agreed upon and designed a National database of NSM. Centers with at least 150 cancers per year and following the National follow-up schedule guidelines could participate inserting any NSM case performed, retrospectively and prospectively from that moment on. In March 2015 analysis of data was accomplished. Dataset for this study consists of cases performed in the period between January 1st 2009 and December 31st 2014. Results: 913 Women were included in the analysis, for a total of 1006 procedures. Prophylactic mastectomies were 124 (12.3%). MRI utilization increased over time. NSM failure rate, with NAC removal for any reason was 11.5%. NAC necrosis rate was 4.8%. Larger skin-flap necrosis rate was 2.3%. Major surgical complications rate was 4.4%. Oncological outcomes were calculated among primitive EBC cases only: locoregional recurrences rate was 2.9%, NAC recurrence 0.7%. Systemic recurrence rate was 1.0%. Five deaths (0.7%) were registered. Conclusions: More than 10% of NSM procedures are prophylactic mastectomies. MRI is gaining more importance over time. Surgical and oncological results show that NSM is effective. This National multicentric analysis enables a comparison of results with no geographical differences and a "safe" state of the art of NSM in Italy.
| Original language | English |
|---|---|
| Pages (from-to) | 75-81 |
| Number of pages | 7 |
| Journal | Breast |
| Volume | 25 |
| DOIs | |
| Publication status | Published - Feb 1 2016 |
Fingerprint
Keywords
- Locoregional breast recurrences
- National registry
- Nipple areola complex necrosis
- Nipple areola complex recurrences
- Nipple sparing mastectomy
ASJC Scopus subject areas
- Surgery
Cite this
Nipple sparing mastectomy : Surgical and oncological outcomes from a national multicentric registry with 913 patients (1006 cases) over a six year period. / Orzalesi, Lorenzo; Casella, Donato; Santi, Caterina; Cecconi, Lorenzo; Murgo, Roberto; Rinaldi, Stefano; Regolo, Lea; Amanti, Claudio; Roncella, Manuela; Serra, Margherita; Meneghini, Graziano; Bortolini, Massimiliano; Altomare, Vittorio; Cabula, Carlo; Catalano, Francesca; Cirilli, Alfredo; Caruso, Francesco; Lazzaretti, Maria Grazia; Cataliotti, Luigi; Bernini, Marco.
In: Breast, Vol. 25, 01.02.2016, p. 75-81.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nipple sparing mastectomy
T2 - Surgical and oncological outcomes from a national multicentric registry with 913 patients (1006 cases) over a six year period
AU - Orzalesi, Lorenzo
AU - Casella, Donato
AU - Santi, Caterina
AU - Cecconi, Lorenzo
AU - Murgo, Roberto
AU - Rinaldi, Stefano
AU - Regolo, Lea
AU - Amanti, Claudio
AU - Roncella, Manuela
AU - Serra, Margherita
AU - Meneghini, Graziano
AU - Bortolini, Massimiliano
AU - Altomare, Vittorio
AU - Cabula, Carlo
AU - Catalano, Francesca
AU - Cirilli, Alfredo
AU - Caruso, Francesco
AU - Lazzaretti, Maria Grazia
AU - Cataliotti, Luigi
AU - Bernini, Marco
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Nipple sparing mastectomy is deemed surgically and oncologically safe based on a long lasting literature data from reviews of single institution series. This study aims at evaluating surgical and oncological outcomes of NSM on a large multi-institutional scale, by means of the Italian National registry. Methods: In July 2011 a panel of Italian specialists agreed upon and designed a National database of NSM. Centers with at least 150 cancers per year and following the National follow-up schedule guidelines could participate inserting any NSM case performed, retrospectively and prospectively from that moment on. In March 2015 analysis of data was accomplished. Dataset for this study consists of cases performed in the period between January 1st 2009 and December 31st 2014. Results: 913 Women were included in the analysis, for a total of 1006 procedures. Prophylactic mastectomies were 124 (12.3%). MRI utilization increased over time. NSM failure rate, with NAC removal for any reason was 11.5%. NAC necrosis rate was 4.8%. Larger skin-flap necrosis rate was 2.3%. Major surgical complications rate was 4.4%. Oncological outcomes were calculated among primitive EBC cases only: locoregional recurrences rate was 2.9%, NAC recurrence 0.7%. Systemic recurrence rate was 1.0%. Five deaths (0.7%) were registered. Conclusions: More than 10% of NSM procedures are prophylactic mastectomies. MRI is gaining more importance over time. Surgical and oncological results show that NSM is effective. This National multicentric analysis enables a comparison of results with no geographical differences and a "safe" state of the art of NSM in Italy.
AB - Background: Nipple sparing mastectomy is deemed surgically and oncologically safe based on a long lasting literature data from reviews of single institution series. This study aims at evaluating surgical and oncological outcomes of NSM on a large multi-institutional scale, by means of the Italian National registry. Methods: In July 2011 a panel of Italian specialists agreed upon and designed a National database of NSM. Centers with at least 150 cancers per year and following the National follow-up schedule guidelines could participate inserting any NSM case performed, retrospectively and prospectively from that moment on. In March 2015 analysis of data was accomplished. Dataset for this study consists of cases performed in the period between January 1st 2009 and December 31st 2014. Results: 913 Women were included in the analysis, for a total of 1006 procedures. Prophylactic mastectomies were 124 (12.3%). MRI utilization increased over time. NSM failure rate, with NAC removal for any reason was 11.5%. NAC necrosis rate was 4.8%. Larger skin-flap necrosis rate was 2.3%. Major surgical complications rate was 4.4%. Oncological outcomes were calculated among primitive EBC cases only: locoregional recurrences rate was 2.9%, NAC recurrence 0.7%. Systemic recurrence rate was 1.0%. Five deaths (0.7%) were registered. Conclusions: More than 10% of NSM procedures are prophylactic mastectomies. MRI is gaining more importance over time. Surgical and oncological results show that NSM is effective. This National multicentric analysis enables a comparison of results with no geographical differences and a "safe" state of the art of NSM in Italy.
KW - Locoregional breast recurrences
KW - National registry
KW - Nipple areola complex necrosis
KW - Nipple areola complex recurrences
KW - Nipple sparing mastectomy
UR - http://www.scopus.com/inward/record.url?scp=84959130759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959130759&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2015.10.010
DO - 10.1016/j.breast.2015.10.010
M3 - Article
AN - SCOPUS:84959130759
VL - 25
SP - 75
EP - 81
JO - Breast
JF - Breast
SN - 0960-9776
ER -