Nitrendipine 20 MG once daily versus nicardipine slow release 40 MG twice daily in mild essential hypertension: Evaluation by 24-hour ambulatory blood pressure monitoring

R. Fogari, F. Tettamanti, A. Zoppi, L. Poletti, G. D. Malamani, L. Corradi, C. Borgnino

Research output: Contribution to journalArticlepeer-review

Abstract

The extent and duration of the blood pressure (BP) lowering effect of 20 mg nitrendipine (NIT) once daily and 40 mg nicardipine slow release (NIC) twice daily were compared in 12 men (aged 39-55 years) with mild essential hypertension according to a randomized, cross over study. Twenty-four-hour non invasive ambulatory BP monitoring (Spacelabs 5200) was performed at the end of a 2-week placebo run-in and after 4 weeks of each active treatment; automatic BP measurements were programmed at 15-min intervals. Both treatments significantly (p>01) reduced mean 24-hour and daytime systolic (SBP) and diastolic (DBP) BP, but had different effects on daytime BP profiles. NIT decreased SBP and DBP (p

Original languageEnglish
Pages (from-to)587-596
Number of pages10
JournalClinical and Experimental Hypertension
VolumeA14
Issue number4
DOIs
Publication statusPublished - 1992

Keywords

  • Ambulatory blood pressure monitoring
  • Calcium Antagonists
  • Hypertension
  • Nicardipine
  • Nitrendipine

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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