TY - JOUR
T1 - Nitrendipine-induced subacute cutaneous lupus erythematosus
AU - Marzano, Angelo V.
AU - Borghi, Alessandro
AU - Mercogliano, Maurizio
AU - Facchetti, Maura
AU - Caputo, Ruggero
PY - 2003/3
Y1 - 2003/3
N2 - A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
AB - A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
KW - Antiphospholipid syndrome
KW - Drug-induced subacute cutaneous lupus erythematosus
KW - Nitrendipine
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M3 - Article
C2 - 12695145
AN - SCOPUS:0037357937
VL - 13
SP - 213
EP - 216
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 2
ER -