Nitrendipine-induced subacute cutaneous lupus erythematosus

Angelo V. Marzano; Alessandro Borghi; Maurizio Mercogliano; Maura Facchetti; Ruggero Caputo

Nitrendipine-induced subacute cutaneous lupus erythematosus

Angelo V. Marzano, Alessandro Borghi, Maurizio Mercogliano, Maura Facchetti, Ruggero Caputo

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	European Journal of Dermatology
Volume	13
Issue number	2
Publication status	Published - Mar 2003

Keywords

Antiphospholipid syndrome
Drug-induced subacute cutaneous lupus erythematosus
Nitrendipine

ASJC Scopus subject areas

Dermatology

Cite this

@article{285531728d3e4a62ac2e87525eb51df3,

title = "Nitrendipine-induced subacute cutaneous lupus erythematosus",

abstract = "A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.",

keywords = "Antiphospholipid syndrome, Drug-induced subacute cutaneous lupus erythematosus, Nitrendipine",

author = "Marzano, {Angelo V.} and Alessandro Borghi and Maurizio Mercogliano and Maura Facchetti and Ruggero Caputo",

year = "2003",

month = mar,

language = "English",

volume = "13",

pages = "213--216",

journal = "European Journal of Dermatology",

issn = "1167-1122",

publisher = "NLM (Medline)",

number = "2",

}

TY - JOUR

T1 - Nitrendipine-induced subacute cutaneous lupus erythematosus

AU - Marzano, Angelo V.

AU - Borghi, Alessandro

AU - Mercogliano, Maurizio

AU - Facchetti, Maura

AU - Caputo, Ruggero

PY - 2003/3

Y1 - 2003/3

N2 - A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.

AB - A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.

KW - Antiphospholipid syndrome

KW - Drug-induced subacute cutaneous lupus erythematosus

KW - Nitrendipine

UR - http://www.scopus.com/inward/record.url?scp=0037357937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037357937&partnerID=8YFLogxK

M3 - Article

C2 - 12695145

AN - SCOPUS:0037357937

VL - 13

SP - 213

EP - 216

JO - European Journal of Dermatology

JF - European Journal of Dermatology

SN - 1167-1122

IS - 2

ER -

Nitrendipine-induced subacute cutaneous lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this