Nitric oxide, ceramide and sphingomyelinase-coupled receptors: A tale of enzymes and messengers coordinating cell death, survival and differentiation

Cristiana Perrotta, Clara De Palma, Sestina Falcone, Clara Sciorati, Emilio Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

The gaseous messenger nitric oxide plays a role in a variety of biological functions. Evidence accumulated over the last 7 years indicates that functions of nitric oxide in apoptosis growth and differentiation may originate in part from an interplay with signalling members of the sphingolipid family. Interactions between nitric oxide and sphingolipids have been shown to be multiple, to involve regulation of activity and expression of the enzymes responsible for the synthesis of nitric oxide and of those involved in the sphingolipid metabolic pathways. Recent evidence indicates that one of these interactions, namely the cross-talk of sphingomyelinases and their product ceramide with nitric oxide and its generating enzyme endothelial nitric oxide synthase, plays prominent roles during key patho-physiological processes such as inflammation, proliferation, death and differentiation.

Original languageEnglish
Pages (from-to)1732-1739
Number of pages8
JournalLife Sciences
Volume77
Issue number14
DOIs
Publication statusPublished - Aug 19 2005

Keywords

  • Apoptosis
  • Ceramide
  • Cyclic GMP
  • Nitric oxide
  • Nitric oxide synthases
  • Sphingolipids
  • Sphingomyelinases

ASJC Scopus subject areas

  • Pharmacology

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