Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats

Alberto Radaelli, Luca Mircoli, Ileana Mori, Giuseppe Mancia, Alberto U. Ferrari

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)-mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO- dependent vasodilation from the pressor response to NO synthesis inhibition by N(G)-monomethyl-L-arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar- Kyoto rats (WKY) were used as controls. The pressor responses to L-NMMA (100 mg · kg-1 IV bolus plus 1.5 mg · kg-1 · min-1 infusion for 60 minutes) as well as to non-NO-dependent pressor stimuli, namely, vasopressin (2, 4, and 8 ng · kg-1) and phenylephrine (0.5, 1, and 2 μg · kg-1) given as IV boluses, were assessed both under control conditions and during suppression of autonomic reflexes by hexamethonium (30 mg · kg-1 IV bolus+1.5 mg · kg-1 · min-1 infusion). Rather than being reduced, the pressor responses to L-NMMA were 39% and 71% larger in the control and areflexic conditions, respectively, than those observed in WKY (both P

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalHypertension
Volume32
Issue number4
Publication statusPublished - Oct 1998

Fingerprint

omega-N-Methylarginine
Inbred SHR Rats
Vasodilation
Nitric Oxide
Inbred WKY Rats
Hexamethonium
Phenylephrine
Vasopressins
Oxides
Reflex
Arginine
Hypertension

Keywords

  • Hexamethonium
  • L-NAME
  • Nitric oxide
  • Rats, inbred SHR
  • Vascular reactivity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Radaelli, A., Mircoli, L., Mori, I., Mancia, G., & Ferrari, A. U. (1998). Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats. Hypertension, 32(4), 735-739.

Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats. / Radaelli, Alberto; Mircoli, Luca; Mori, Ileana; Mancia, Giuseppe; Ferrari, Alberto U.

In: Hypertension, Vol. 32, No. 4, 10.1998, p. 735-739.

Research output: Contribution to journalArticle

Radaelli, A, Mircoli, L, Mori, I, Mancia, G & Ferrari, AU 1998, 'Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats', Hypertension, vol. 32, no. 4, pp. 735-739.
Radaelli A, Mircoli L, Mori I, Mancia G, Ferrari AU. Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats. Hypertension. 1998 Oct;32(4):735-739.
Radaelli, Alberto ; Mircoli, Luca ; Mori, Ileana ; Mancia, Giuseppe ; Ferrari, Alberto U. / Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats. In: Hypertension. 1998 ; Vol. 32, No. 4. pp. 735-739.
@article{52f790c410924207be44a126ff75296e,
title = "Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats",
abstract = "Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)-mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO- dependent vasodilation from the pressor response to NO synthesis inhibition by N(G)-monomethyl-L-arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar- Kyoto rats (WKY) were used as controls. The pressor responses to L-NMMA (100 mg · kg-1 IV bolus plus 1.5 mg · kg-1 · min-1 infusion for 60 minutes) as well as to non-NO-dependent pressor stimuli, namely, vasopressin (2, 4, and 8 ng · kg-1) and phenylephrine (0.5, 1, and 2 μg · kg-1) given as IV boluses, were assessed both under control conditions and during suppression of autonomic reflexes by hexamethonium (30 mg · kg-1 IV bolus+1.5 mg · kg-1 · min-1 infusion). Rather than being reduced, the pressor responses to L-NMMA were 39{\%} and 71{\%} larger in the control and areflexic conditions, respectively, than those observed in WKY (both P",
keywords = "Hexamethonium, L-NAME, Nitric oxide, Rats, inbred SHR, Vascular reactivity",
author = "Alberto Radaelli and Luca Mircoli and Ileana Mori and Giuseppe Mancia and Ferrari, {Alberto U.}",
year = "1998",
month = "10",
language = "English",
volume = "32",
pages = "735--739",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Nitric oxide-dependent vasodilation in young spontaneously hypertensive rats

AU - Radaelli, Alberto

AU - Mircoli, Luca

AU - Mori, Ileana

AU - Mancia, Giuseppe

AU - Ferrari, Alberto U.

PY - 1998/10

Y1 - 1998/10

N2 - Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)-mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO- dependent vasodilation from the pressor response to NO synthesis inhibition by N(G)-monomethyl-L-arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar- Kyoto rats (WKY) were used as controls. The pressor responses to L-NMMA (100 mg · kg-1 IV bolus plus 1.5 mg · kg-1 · min-1 infusion for 60 minutes) as well as to non-NO-dependent pressor stimuli, namely, vasopressin (2, 4, and 8 ng · kg-1) and phenylephrine (0.5, 1, and 2 μg · kg-1) given as IV boluses, were assessed both under control conditions and during suppression of autonomic reflexes by hexamethonium (30 mg · kg-1 IV bolus+1.5 mg · kg-1 · min-1 infusion). Rather than being reduced, the pressor responses to L-NMMA were 39% and 71% larger in the control and areflexic conditions, respectively, than those observed in WKY (both P

AB - Conflicting evidence exists on the possible impairment of tonic nitric oxide (NO)-mediated vasodilation as a causative factor in the genesis of human as well as experimental hypertension. We evaluated the tonic NO- dependent vasodilation from the pressor response to NO synthesis inhibition by N(G)-monomethyl-L-arginine (L-NMMA) in 9 conscious, chronically instrumented spontaneously hypertensive rats (SHR) at 12 weeks of age, ie, during the early established hypertensive stage. Nine age-matched Wistar- Kyoto rats (WKY) were used as controls. The pressor responses to L-NMMA (100 mg · kg-1 IV bolus plus 1.5 mg · kg-1 · min-1 infusion for 60 minutes) as well as to non-NO-dependent pressor stimuli, namely, vasopressin (2, 4, and 8 ng · kg-1) and phenylephrine (0.5, 1, and 2 μg · kg-1) given as IV boluses, were assessed both under control conditions and during suppression of autonomic reflexes by hexamethonium (30 mg · kg-1 IV bolus+1.5 mg · kg-1 · min-1 infusion). Rather than being reduced, the pressor responses to L-NMMA were 39% and 71% larger in the control and areflexic conditions, respectively, than those observed in WKY (both P

KW - Hexamethonium

KW - L-NAME

KW - Nitric oxide

KW - Rats, inbred SHR

KW - Vascular reactivity

UR - http://www.scopus.com/inward/record.url?scp=0031753507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031753507&partnerID=8YFLogxK

M3 - Article

C2 - 9774372

AN - SCOPUS:0031753507

VL - 32

SP - 735

EP - 739

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -