Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview

Louis J. Ignarro; Claudio Napoli; Joseph Loscalzo

doi:10.1161/hh0102.102330

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview

Louis J. Ignarro, Claudio Napoli, Joseph Loscalzo

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Abstract

Nitric oxide (NO) mediates multiple physiological and pathophysiological processes in the cardiovascular system. Pharmacological compounds that release NO have been useful tools for evaluating the pivotal role of NO in cardiovascular physiology and therapeutics. These agents constitute two broad classes of compounds, those that release NO or one of its redox congeners spontaneously and those that require enzymatic metabolism to generate NO. In addition, several commonly used cardiovascular drugs exert their beneficial action, in part, by modulating the NO pathway. Here, we review these classes of agents, summarizing their fundamental chemistry and pharmacology, and provide an overview of their cardiovascular mechanisms of action.

Original language	English
Pages (from-to)	21-28
Number of pages	8
Journal	Circulation Research
Volume	90
Issue number	1
DOIs	https://doi.org/10.1161/hh0102.102330
Publication status	Published - Jan 11 2002

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Keywords

Cardiovascular pharmacology
Endothelium
Nitric oxide
Oxidant stress
Vascular type

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

Ignarro, L. J., Napoli, C., & Loscalzo, J. (2002). Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview. Circulation Research, 90(1), 21-28. https://doi.org/10.1161/hh0102.102330

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10.1161/hh0102.102330