Nitric oxide: Emerging concepts about its use in cell-based therapies

Silvia Brunelli, Patrizia Rovere-Querini, Clara Sciorati, Angelo A. Manfredi, Emilio Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Regenerative medicine is an emerging clinical discipline in which cell-based therapies are used to restore the functions of damaged or defective tissues and organs. Along with the well-established use of cells derived from bone marrow or pancreatic islets, novel approaches of cell therapy have recently emerged that appear particularly promising; that is, those using cell-based vaccines and stem cells. This review focuses on the recent developments of these experimental therapeutic approaches and their drawbacks, with specific focus on dendritic cell vaccines in tumours and mesoangioblasts in muscular dystrophies. The authors discuss how the unique properties of a gaseous messenger, NO, may be exploited to overcome some of the draw-backs of these cell-based approaches in combined therapies based on NO-releasing drugs and cell delivery.

Original languageEnglish
Pages (from-to)33-43
Number of pages11
JournalExpert Opinion on Investigational Drugs
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Cell-based vaccines
  • cGMP
  • Dendritic cells
  • Lymphocytes
  • Mesoangioblasts
  • Muscular dystrophy
  • NO-releasing drugs
  • Sphingolipids
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology

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