Nitric oxide limits parasite development in vectors and in invertebrate intermediate hosts

Luigi Gradoni, Paolo Ascenzi

Research output: Contribution to journalArticle


Nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa in vertebrate definitive and intermediate hosts. Inducible NO limits parasite development also in Rhodnius prolixus and Anopheles stephensi, the natural vectors of human trypanosomiasis and malaria respectively, and in the snail Biomphalaria glabrata, a natural invertebrate intermediate host of human schistosomiasis. Therefore, NO limits Trypanosoma, Plasmodium, and Schistosoma development at all stages of the parasite life cycle.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalIUBMB Life
Issue number2
Publication statusPublished - 2002



  • Antiparasitic effect of NO
  • Nitric oxide
  • Parasite development

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this