Nitric oxide limits parasite development in vectors and in invertebrate intermediate hosts

Luigi Gradoni, Paolo Ascenzi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa in vertebrate definitive and intermediate hosts. Inducible NO limits parasite development also in Rhodnius prolixus and Anopheles stephensi, the natural vectors of human trypanosomiasis and malaria respectively, and in the snail Biomphalaria glabrata, a natural invertebrate intermediate host of human schistosomiasis. Therefore, NO limits Trypanosoma, Plasmodium, and Schistosoma development at all stages of the parasite life cycle.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalIUBMB Life
Volume53
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Invertebrates
Nitric Oxide
Parasites
Rhodnius
Protozoa
Biomphalaria
Schistosoma
Trypanosoma
Antiparasitic Agents
Anopheles
Plasmodium
Trypanosomiasis
Schistosomiasis
Snails
Life Cycle Stages
Malaria
Vertebrates
Life cycle

Keywords

  • Antiparasitic effect of NO
  • Nitric oxide
  • Parasite development

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Nitric oxide limits parasite development in vectors and in invertebrate intermediate hosts. / Gradoni, Luigi; Ascenzi, Paolo.

In: IUBMB Life, Vol. 53, No. 2, 2002, p. 121-123.

Research output: Contribution to journalArticle

Gradoni, Luigi ; Ascenzi, Paolo. / Nitric oxide limits parasite development in vectors and in invertebrate intermediate hosts. In: IUBMB Life. 2002 ; Vol. 53, No. 2. pp. 121-123.
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