Nitric oxide metabolites in allergic rhinitis: The effect of pollen allergen exposure

G. Ciprandi, M. Tosca, D. Fuchs

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Seasonal allergic rhinitis (SAR) is characterised by an inflammation consequent to allergen exposure. Nitric oxide may be involved in allergic inflammation. Objective: This study evaluated the serum nitrite concentrations in SAR patients during and outside pollen exposure in order to estimate activity of nitric oxide synthases. Methods: One hundred and two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with SAR evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Serum concentrations of nitrite were measured and in those patients exposed to pollens, results were compared to scores of the Visual Analogue Scale for nasal obstruction perception. Results: Serum nitrite concentrations were higher in SAR patients evaluated outside the pollen season ( U = -6.78; p

Original languageEnglish
Pages (from-to)326-329
Number of pages4
JournalAllergologia et Immunopathologia
Volume39
Issue number6
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Allergic rhinitis
  • Nitrite
  • Pollen allergen exposure
  • Serum

ASJC Scopus subject areas

  • Immunology and Allergy

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