Nitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunction

Alessandra Magenta, Simona Greco, Maurizio C. Capogrossi, Carlo Gaetano, Fabio Martelli

Research output: Contribution to journalArticlepeer-review


Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, p 66 S h c protein.

Original languageEnglish
Article number193095
JournalBioMed Research International
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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