Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia

Costanza Emanueli, Sophie Van Linthout, Maria Bonaria Salis, Angela Monopoli, Piero Del Soldato, Ennio Ongini, Paolo Madeddu

Research output: Contribution to journalArticle

Abstract

Background - Recently, nitric oxide (NO) donors have been developed that mimic the physiological intracellular release of NO. We evaluated whether one of these new compounds, consisting of aspirin coupled to an NO-releasing moiety (NCX 4016), would protect limbs from supervening arterial occlusion. Methods and Results - Mice were assigned to receive regular chow or chow containing NCX 4016 or aspirin (both at 300 μmol/kg body weight, daily) throughout the 3-week experimental period. One week after randomization, they underwent surgical excision of the left femoral artery. Limb blood flow recovery (laser Doppler flowmetry) was accelerated by NCX 4016 as compared with aspirin or vehicle (P

Original languageEnglish
Pages (from-to)2082-2087
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2004

Keywords

  • Angiogenesis
  • Apoptosis
  • Endothelial cell
  • Ischemia
  • Peripheral vascular disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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