Nitric Oxide-Releasing Drugs

Claudio Napoli, Louis J. Ignarro

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Pharmacological compounds that release nitric oxide (NO) have been useful tools for evaluating the broad role of NO in physiology and therapeutics. NO deficiency has been implicated in the genesis and evolution of several disease states. Both medical needs and commercial opportunities have fostered attempts to modulate NO in the human body for therapeutic gain. Strategies for NO modulation encompass antiinflammatory, sexual dysfunction, and cardiovascular indications. Apart from newly developed drugs, several commonly used cardiovascular drugs exert their beneficial action, at least in part, by modulating the NO pathway. This review discusses the fundamental pharmacological properties and mechanisms of action of NO-releasing drugs. Some of these compounds may enter in the clinical arena providing important therapeutic benefits in human diseases.

Original languageEnglish
Pages (from-to)97-123
Number of pages27
JournalAnnual Review of Pharmacology and Toxicology
Volume43
DOIs
Publication statusPublished - 2003

Fingerprint

Nitric Oxide
Pharmaceutical Preparations
Molecular Mechanisms of Pharmacological Action
Cardiovascular Agents
Physiology
Human Body
Anti-Inflammatory Agents
Therapeutics
Modulation
Pharmacology

Keywords

  • β-blockers
  • ACE-inhibitors
  • Cardiovascular disease
  • Nitroprusside
  • NO-aspirin
  • S-nitrosothiols

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Nitric Oxide-Releasing Drugs. / Napoli, Claudio; Ignarro, Louis J.

In: Annual Review of Pharmacology and Toxicology, Vol. 43, 2003, p. 97-123.

Research output: Contribution to journalArticle

Napoli, Claudio ; Ignarro, Louis J. / Nitric Oxide-Releasing Drugs. In: Annual Review of Pharmacology and Toxicology. 2003 ; Vol. 43. pp. 97-123.
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