Nitrile oxide cycloaddition of non-activated alkynes

A novel approach to the synthesis of neuroactive isoxazoles

Paolo Pevarello, Raffaella Amici, Maristella Colombo, Mario Varasi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A general method for the unprecedented 1,3-dipolar cycloaddition of bromonitrile oxide to disubstituted non-activated alkynes provides a useful alternative route to the neuropharmacological tools AMPA and 4-methylhomoibotenic acid.

Original languageEnglish
Pages (from-to)2151-2152
Number of pages2
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number18
Publication statusPublished - 1993

Fingerprint

Isoxazoles
Nitriles
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Alkynes
Cycloaddition
Oxides
4-methylhomoibotenic acid

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Nitrile oxide cycloaddition of non-activated alkynes : A novel approach to the synthesis of neuroactive isoxazoles. / Pevarello, Paolo; Amici, Raffaella; Colombo, Maristella; Varasi, Mario.

In: Journal of the Chemical Society. Perkin Transactions 1, No. 18, 1993, p. 2151-2152.

Research output: Contribution to journalArticle

Pevarello, Paolo ; Amici, Raffaella ; Colombo, Maristella ; Varasi, Mario. / Nitrile oxide cycloaddition of non-activated alkynes : A novel approach to the synthesis of neuroactive isoxazoles. In: Journal of the Chemical Society. Perkin Transactions 1. 1993 ; No. 18. pp. 2151-2152.
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