Nitrile oxide cycloaddition of non-activated alkynes: A novel approach to the synthesis of neuroactive isoxazoles

Paolo Pevarello, Raffaella Amici, Maristella Colombo, Mario Varasi

Research output: Contribution to journalArticle


A general method for the unprecedented 1,3-dipolar cycloaddition of bromonitrile oxide to disubstituted non-activated alkynes provides a useful alternative route to the neuropharmacological tools AMPA and 4-methylhomoibotenic acid.

Original languageEnglish
Pages (from-to)2151-2152
Number of pages2
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number18
Publication statusPublished - 1993


ASJC Scopus subject areas

  • Chemistry(all)

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