Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

Chiara Demartini; Rosaria Greco; Anna Maria Zanaboni; Grazia Sances; Roberto De Icco; David Borsook; Cristina Tassorelli

doi:10.1016/j.pneurobio.2019.02.002

Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Grazia Sances, Roberto De Icco, David Borsook, Cristina Tassorelli

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Review article › peer-review

Abstract

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

Original language	English
Pages (from-to)	15-32
Number of pages	17
Journal	Progress in Neurobiology
Volume	177
DOIs	https://doi.org/10.1016/j.pneurobio.2019.02.002
Publication status	Published - Jan 1 2019

Keywords

Animal model
Migraine
Migraneurs
Nitroglycerin

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/j.pneurobio.2019.02.002

Fingerprint Dive into the research topics of 'Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back'. Together they form a unique fingerprint.

Cite this

@article{2daf618fa01a46a5a928146106dd6601,

title = "Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back",

abstract = "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.",

keywords = "Animal model, Migraine, Migraneurs, Nitroglycerin",

author = "Chiara Demartini and Rosaria Greco and Zanaboni, {Anna Maria} and Grazia Sances and {De Icco}, Roberto and David Borsook and Cristina Tassorelli",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.pneurobio.2019.02.002",

language = "English",

volume = "177",

pages = "15--32",

journal = "Progress in Neurobiology",

issn = "0301-0082",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Nitroglycerin as a comparative experimental model of migraine pain

T2 - From animal to human and back

AU - Demartini, Chiara

AU - Greco, Rosaria

AU - Zanaboni, Anna Maria

AU - Sances, Grazia

AU - De Icco, Roberto

AU - Borsook, David

AU - Tassorelli, Cristina

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

AB - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

KW - Animal model

KW - Migraine

KW - Migraneurs

KW - Nitroglycerin

UR - http://www.scopus.com/inward/record.url?scp=85061846285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061846285&partnerID=8YFLogxK

U2 - 10.1016/j.pneurobio.2019.02.002

DO - 10.1016/j.pneurobio.2019.02.002

M3 - Review article

AN - SCOPUS:85061846285

VL - 177

SP - 15

EP - 32

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

ER -