Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

Research output: Contribution to journalReview article

Abstract

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

Original languageEnglish
Pages (from-to)15-32
Number of pages17
JournalProgress in Neurobiology
Volume177
DOIs
Publication statusPublished - Jan 1 2019

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Nitroglycerin
Migraine Disorders
Theoretical Models
Pain
Nitrates
Blood Vessels
Head
Brain
Pharmaceutical Preparations

Keywords

  • Animal model
  • Migraine
  • Migraneurs
  • Nitroglycerin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back",
abstract = "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.",
keywords = "Animal model, Migraine, Migraneurs, Nitroglycerin",
author = "Chiara Demartini and Rosaria Greco and Zanaboni, {Anna Maria} and Grazia Sances and {De Icco}, Roberto and David Borsook and Cristina Tassorelli",
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T2 - From animal to human and back

AU - Demartini, Chiara

AU - Greco, Rosaria

AU - Zanaboni, Anna Maria

AU - Sances, Grazia

AU - De Icco, Roberto

AU - Borsook, David

AU - Tassorelli, Cristina

PY - 2019/1/1

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N2 - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

AB - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.

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KW - Migraneurs

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