Abstract
Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.
| Original language | English |
|---|---|
| Pages (from-to) | 15-32 |
| Number of pages | 17 |
| Journal | Progress in Neurobiology |
| Volume | 177 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Animal model
- Migraine
- Migraneurs
- Nitroglycerin
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Nitroglycerin as a comparative experimental model of migraine pain : From animal to human and back. / Demartini, Chiara; Greco, Rosaria; Zanaboni, Anna Maria; Sances, Grazia; De Icco, Roberto; Borsook, David; Tassorelli, Cristina.
In: Progress in Neurobiology, Vol. 177, 01.01.2019, p. 15-32.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nitroglycerin as a comparative experimental model of migraine pain
T2 - From animal to human and back
AU - Demartini, Chiara
AU - Greco, Rosaria
AU - Zanaboni, Anna Maria
AU - Sances, Grazia
AU - De Icco, Roberto
AU - Borsook, David
AU - Tassorelli, Cristina
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.
AB - Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. A better understanding of the nature of these changes and how well they parallel a true migraine attack would allow for a translational model to better understand some of the mechanisms involved in the generation of a migraine attack. The present review summarizes the known body of knowledge of nitroglycerin effects evaluated in humans and animals as it relates to potential mechanisms associated with migraine headaches.
KW - Animal model
KW - Migraine
KW - Migraneurs
KW - Nitroglycerin
UR - http://www.scopus.com/inward/record.url?scp=85061846285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061846285&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2019.02.002
DO - 10.1016/j.pneurobio.2019.02.002
M3 - Review article
AN - SCOPUS:85061846285
VL - 177
SP - 15
EP - 32
JO - Progress in Neurobiology
JF - Progress in Neurobiology
SN - 0301-0082
ER -