Abstract
Background: Nitroglycerin (NTG) is known to increase the blood supply to the myocardium, and would thus increase the delivery of a perfusional tracer such as sestamibi (MIBI) to the tissue. The latter, in turn, would take up and concentrate the tracer to a greater extent than in basal conditions only if energy-dependent mechanisms were still available - that is, only if the cells were still viable. Methods: We evaluated the changes that intravenous administration of NTG induced on the uptake of MIBI by akinetic myocardial areas, using tomographic perfusional imaging in 23 patients with previously ascertained anterior myocardial infarction who were undergoing myocardial revascularization procedures. Changes in uptake were compared with echocardiographic and perfusional changes occurring after operation. Results: The improvement of MIBI uptake after NTG correctly identified 12 of the 16 patients (75%) showing postoperative wall motion improvement; they comprised 12 of the 14 (86%) patients with NTG-induced increase in MIBI uptake who showed improved wall motion after operation. A close correlation (r = 0.88, P <0.001) was found between the increase in myocardial MIBI uptake induced by NTG infusion and that induced by revascularization. The presence of collaterals to the akinetic area was associated with a significantly (P <0.01) greater increase in MIBI uptake both during NTG infusion and after operation. Conclusions: The results of this study suggest that MIBI perfusional myocardial scintigraphy during infusion of NTG is capable of detecting viable but chronically hypoperfused myocardium, predicting postoperative wall motion and perfusional improvement, and reflecting the postoperative pattern of perfusion. The best results were achieved in patients with evidence of collateral circulation supplying the infarcted area.
| Original language | English |
|---|---|
| Pages (from-to) | 877-884 |
| Number of pages | 8 |
| Journal | Coronary Artery Disease |
| Volume | 7 |
| Issue number | 12 |
| Publication status | Published - 1996 |
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Keywords
- nitroglycerin
- perfusion
- tomography
- viability
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Nitroglycerin-induced changes in myocardial sestamibi uptake to detect tissue viability : Radionuclide comparison before and after revascularization. / Greco, Cesare; Tanzilli, Gaetano; Ciavolella, Massimo; Sinatra, Riccardo; Banci, Maria; Schillaci, Orazio; Macrina, Francesco; Scopinaro, Francesco; Marino, Benedetto; Campa, Pietro Paolo.
In: Coronary Artery Disease, Vol. 7, No. 12, 1996, p. 877-884.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nitroglycerin-induced changes in myocardial sestamibi uptake to detect tissue viability
T2 - Radionuclide comparison before and after revascularization
AU - Greco, Cesare
AU - Tanzilli, Gaetano
AU - Ciavolella, Massimo
AU - Sinatra, Riccardo
AU - Banci, Maria
AU - Schillaci, Orazio
AU - Macrina, Francesco
AU - Scopinaro, Francesco
AU - Marino, Benedetto
AU - Campa, Pietro Paolo
PY - 1996
Y1 - 1996
N2 - Background: Nitroglycerin (NTG) is known to increase the blood supply to the myocardium, and would thus increase the delivery of a perfusional tracer such as sestamibi (MIBI) to the tissue. The latter, in turn, would take up and concentrate the tracer to a greater extent than in basal conditions only if energy-dependent mechanisms were still available - that is, only if the cells were still viable. Methods: We evaluated the changes that intravenous administration of NTG induced on the uptake of MIBI by akinetic myocardial areas, using tomographic perfusional imaging in 23 patients with previously ascertained anterior myocardial infarction who were undergoing myocardial revascularization procedures. Changes in uptake were compared with echocardiographic and perfusional changes occurring after operation. Results: The improvement of MIBI uptake after NTG correctly identified 12 of the 16 patients (75%) showing postoperative wall motion improvement; they comprised 12 of the 14 (86%) patients with NTG-induced increase in MIBI uptake who showed improved wall motion after operation. A close correlation (r = 0.88, P <0.001) was found between the increase in myocardial MIBI uptake induced by NTG infusion and that induced by revascularization. The presence of collaterals to the akinetic area was associated with a significantly (P <0.01) greater increase in MIBI uptake both during NTG infusion and after operation. Conclusions: The results of this study suggest that MIBI perfusional myocardial scintigraphy during infusion of NTG is capable of detecting viable but chronically hypoperfused myocardium, predicting postoperative wall motion and perfusional improvement, and reflecting the postoperative pattern of perfusion. The best results were achieved in patients with evidence of collateral circulation supplying the infarcted area.
AB - Background: Nitroglycerin (NTG) is known to increase the blood supply to the myocardium, and would thus increase the delivery of a perfusional tracer such as sestamibi (MIBI) to the tissue. The latter, in turn, would take up and concentrate the tracer to a greater extent than in basal conditions only if energy-dependent mechanisms were still available - that is, only if the cells were still viable. Methods: We evaluated the changes that intravenous administration of NTG induced on the uptake of MIBI by akinetic myocardial areas, using tomographic perfusional imaging in 23 patients with previously ascertained anterior myocardial infarction who were undergoing myocardial revascularization procedures. Changes in uptake were compared with echocardiographic and perfusional changes occurring after operation. Results: The improvement of MIBI uptake after NTG correctly identified 12 of the 16 patients (75%) showing postoperative wall motion improvement; they comprised 12 of the 14 (86%) patients with NTG-induced increase in MIBI uptake who showed improved wall motion after operation. A close correlation (r = 0.88, P <0.001) was found between the increase in myocardial MIBI uptake induced by NTG infusion and that induced by revascularization. The presence of collaterals to the akinetic area was associated with a significantly (P <0.01) greater increase in MIBI uptake both during NTG infusion and after operation. Conclusions: The results of this study suggest that MIBI perfusional myocardial scintigraphy during infusion of NTG is capable of detecting viable but chronically hypoperfused myocardium, predicting postoperative wall motion and perfusional improvement, and reflecting the postoperative pattern of perfusion. The best results were achieved in patients with evidence of collateral circulation supplying the infarcted area.
KW - nitroglycerin
KW - perfusion
KW - tomography
KW - viability
UR - http://www.scopus.com/inward/record.url?scp=8044258381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8044258381&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 877
EP - 884
JO - Coronary Artery Disease
JF - Coronary Artery Disease
SN - 0954-6928
IS - 12
ER -