Nitroglycerin induces hyperalgesia in rats - A time-course study

Cristina Tassorelli, Rosaria Greco, Dechun Wang, Maurizio Sandrini, Giorgio Sandrini, Giuseppe Nappi

Research output: Contribution to journalArticle


Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration. The effect of nitroglycerin on the nociceptive threshold was studied in rats by means of two experimental tests that explore different modalities of pain: the tail-flick test and the formalin test. Nitroglycerin induced a significant reduction in the latency of the tail flick 2 and 4 h after its administration. Similarly, formalin-induced pain-related behaviour increased significantly 2 and 4 h after nitroglycerin administration.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2-3
Publication statusPublished - Mar 19 2003


  • Formalin test
  • Hyperalgesia
  • Migraine
  • Nitric oxide (NO)
  • Pain
  • Tail-flick test

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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