NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

A. Meneghetti, E. Mariani, S. Santi, M. Riccio, L. Cattini, S. Paoletti, A. Facchini

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Abstract

Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.

Original languageEnglish
Pages (from-to)909-914
Number of pages6
JournalInternational Journal of Oncology
Volume15
Issue number5
Publication statusPublished - Nov 1999

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meneghetti, A., Mariani, E., Santi, S., Riccio, M., Cattini, L., Paoletti, S., & Facchini, A. (1999). NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. International Journal of Oncology, 15(5), 909-914.