NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

A. Meneghetti; E. Mariani; S. Santi; M. Riccio; L. Cattini; S. Paoletti; A. Facchini

NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

A. Meneghetti, E. Mariani, S. Santi, M. Riccio, L. Cattini, S. Paoletti, A. Facchini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.

Original language	English
Pages (from-to)	909-914
Number of pages	6
Journal	International Journal of Oncology
Volume	15
Issue number	5
Publication status	Published - Nov 1999

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.",

abstract = "Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.",

author = "A. Meneghetti and E. Mariani and S. Santi and M. Riccio and L. Cattini and S. Paoletti and A. Facchini",

year = "1999",

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T1 - NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

AU - Meneghetti, A.

AU - Mariani, E.

AU - Santi, S.

AU - Riccio, M.

AU - Cattini, L.

AU - Paoletti, S.

AU - Facchini, A.

PY - 1999/11

Y1 - 1999/11

N2 - Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.

AB - Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.

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M3 - Article

C2 - 10536172

AN - SCOPUS:0033227291

VL - 15

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JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 5

ER -

NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

Abstract

ASJC Scopus subject areas

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