NK cell activating receptors and tumor recognition in humans

C. Bottino, L. Moretta, A. Moretta

Research output: Contribution to journalArticlepeer-review


Natural killer (NK) cells have been known for many years as the lymphocyte subset characterized by the highest cytolytic potential against virus-infected and tumor-transformed cells. A surprisingly high number of surface molecules have been recognized that regulate human NK cell function. These include MHC-specific inhibitory receptors, which impair NK cells' ability to attack normal self-tissues, and activating receptors and coreceptors that allow them to recognize and kill transformed cells. The recent identification of some of the cellular ligands specifically recognized by these receptors/coreceptors contributes to elucidation of the mystery of the role played by NK cells in immune responses.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalCurrent Topics in Microbiology and Immunology
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology
  • Immunology and Allergy
  • Microbiology (medical)


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