NK cell-mediated immune response against cancer

Research output: Contribution to journalArticlepeer-review

Abstract

The past fifteen years have witnessed great progress in our undestanding of how natural killer (NK) cells function, their role in innate defenses and their possibile exploitation in therapy. This contribution traces the major advances in these formerly mysterious cells, from the first discovery of HLA-class I-specific inhibitory receptors to a more recent major breakgthrough that highlighted important perspectives and major expectations regarding the cure of life-threatening leukemias. The key role of "alloreactive" NK cells in eradicating acute myeloid leukemias and in preventing both graft rejection and graft-versus-host disease, led to a true revolution in bone marrow transplantation. Thus, it is now possible to search for appropriate HLA class I mismatches to set NK cells in action to cure high risk leukemias.

Original languageEnglish
Pages (from-to)3-5
Number of pages3
JournalSurgical Oncology
Volume16
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Acute leukemias
  • Natural Killer cells
  • NK receptors

ASJC Scopus subject areas

  • Oncology
  • Surgery

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