NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles

Simona Caruso, Biagio De Angelis, Simona Carlomagno, Francesca Del Bufalo, Simona Sivori, Franco Locatelli, Concetta Quintarelli

Research output: Contribution to journalArticlepeer-review

Abstract

Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalSeminars in Hematology
Volume57
Issue number4
DOIs
Publication statusPublished - Oct 2020

Keywords

  • CAR
  • Genetic modification
  • HSC transplantation
  • Immunotherapy
  • KIRs
  • NK cell

ASJC Scopus subject areas

  • Hematology

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