TY - JOUR
T1 - NK cells as adoptive cellular therapy for hematological malignancies
T2 - Advantages and hurdles
AU - Caruso, Simona
AU - De Angelis, Biagio
AU - Carlomagno, Simona
AU - Del Bufalo, Francesca
AU - Sivori, Simona
AU - Locatelli, Franco
AU - Quintarelli, Concetta
N1 - Funding Information:
The authors would like to thank all agencies supporting our work on immunotherapy, in particular the Italian Health Ministry [for GR-2013-02359212, (C. Quintarelli), GR-2016-02364546- (B. De Angelis), RF- 2016-02364388 (F. Locatelli), CAR T RCR-2019-23669115 (Coordinator F. Locatelli)]; Ministero dell'Università e della Ricerca [for Grant PRIN 2017 (F. Locatelli, S. Sivori)]; AIRC [for Special Project 5 × 1000 no. 9962 (F. Locatelli; S. Sivori), AIRC IG 2018 id. 21724 (F. Locatelli), AIRC IG 2017 id. 20312 (S. Sivori)]; AIFA [Independent Research grant (F. Locatelli PI: 2016 call)]; Cancer Research UK/AIRC [for INCAR project (F. Locatelli)].
Funding Information:
The authors would like to thank all agencies supporting our work on immunotherapy, in particular the Italian Health Ministry [for GR-2013-02359212, (C. Quintarelli), GR-2016-02364546- (B. De Angelis), RF- 2016-02364388 (F. Locatelli), CAR T RCR-2019-23669115 (Coordinator F. Locatelli)]; Ministero dell'Universit? e della Ricerca [for Grant PRIN 2017 (F. Locatelli, S. Sivori)]; AIRC [for Special Project 5???1000 no. 9962 (F. Locatelli; S. Sivori), AIRC IG 2018 id. 21724 (F. Locatelli), AIRC IG 2017 id. 20312 (S. Sivori)]; AIFA [Independent Research grant (F. Locatelli PI: 2016 call)]; Cancer Research UK/AIRC [for INCAR project (F. Locatelli)].
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/10
Y1 - 2020/10
N2 - Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.
AB - Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.
KW - CAR
KW - Genetic modification
KW - HSC transplantation
KW - Immunotherapy
KW - KIRs
KW - NK cell
UR - http://www.scopus.com/inward/record.url?scp=85095952921&partnerID=8YFLogxK
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U2 - 10.1053/j.seminhematol.2020.10.004
DO - 10.1053/j.seminhematol.2020.10.004
M3 - Article
C2 - 33256910
AN - SCOPUS:85095952921
VL - 57
SP - 175
EP - 184
JO - Seminars in Hematology
JF - Seminars in Hematology
SN - 0037-1963
IS - 4
ER -