NK cells from malignant pleural effusions are potent antitumor effectors A clue for adoptive immunotherapy

Paola Vacca, Stefania Martini, Maria C. Mingari, Lorenzo Moretta

Research output: Contribution to journalArticle

Abstract

AbstarctNatural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy.

Original languageEnglish
Article numbere23638
JournalOncoImmunology
Volume2
Issue number4
DOIs
Publication statusPublished - Apr 2013

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Keywords

  • Cancer
  • Immune response
  • Immunotherapy
  • NK cells
  • Tumor immunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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