NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG)

Ornella Della Casa Alberighi, Eduardo Nobile Orazio, Paola Bonara, Cinzia Hu, Giorgio Spagnol, Laura Radelli, Raffaella Scorza Smeraldi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied Leu 7+ cell distribution and natural killer (NK) activity in the peripheral blood of six patients who had peripheral neuropathy and monoclonal IgM protein directed against myelin-associated glycoprotein (anti-MAG IgM). We did not find any difference between patients and control subjects (healthy or polyneuropathic, some with IgM monoclonal paraprotein but without anti-MAG activity). The presence of autologous sera did not interfere with these results. We noted an increase in Leu 11+ cell percentages after pre-incubation of the patient cells with autologous sera but the phenotypes of cells from control subjects did not changes after incubation with autologous or patient sera.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalJournal of Neuroimmunology
Volume18
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Anti-myelin-associated glycoprotein IgM and neuropathy
  • cell-mediated
  • Immunity
  • Myelin-associated glycoprotein
  • Natural killer cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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