We studied Leu 7+ cell distribution and natural killer (NK) activity in the peripheral blood of six patients who had peripheral neuropathy and monoclonal IgM protein directed against myelin-associated glycoprotein (anti-MAG IgM). We did not find any difference between patients and control subjects (healthy or polyneuropathic, some with IgM monoclonal paraprotein but without anti-MAG activity). The presence of autologous sera did not interfere with these results. We noted an increase in Leu 11+ cell percentages after pre-incubation of the patient cells with autologous sera but the phenotypes of cells from control subjects did not changes after incubation with autologous or patient sera.
- Anti-myelin-associated glycoprotein IgM and neuropathy
- Myelin-associated glycoprotein
- Natural killer cell
ASJC Scopus subject areas
- Immunology and Allergy
- Clinical Neurology