NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG)

Ornella Della Casa Alberighi, Eduardo Nobile Orazio, Paola Bonara, Cinzia Hu, Giorgio Spagnol, Laura Radelli, Raffaella Scorza Smeraldi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied Leu 7+ cell distribution and natural killer (NK) activity in the peripheral blood of six patients who had peripheral neuropathy and monoclonal IgM protein directed against myelin-associated glycoprotein (anti-MAG IgM). We did not find any difference between patients and control subjects (healthy or polyneuropathic, some with IgM monoclonal paraprotein but without anti-MAG activity). The presence of autologous sera did not interfere with these results. We noted an increase in Leu 11+ cell percentages after pre-incubation of the patient cells with autologous sera but the phenotypes of cells from control subjects did not changes after incubation with autologous or patient sera.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalJournal of Neuroimmunology
Volume18
Issue number3
DOIs
Publication statusPublished - 1988

Fingerprint

Myelin-Associated Glycoprotein
Peripheral Nervous System Diseases
Natural Killer Cells
Immunoglobulin M
Proteins
Serum
Paraproteins
Healthy Volunteers
Phenotype

Keywords

  • Anti-myelin-associated glycoprotein IgM and neuropathy
  • cell-mediated
  • Immunity
  • Myelin-associated glycoprotein
  • Natural killer cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG). / Della Casa Alberighi, Ornella; Nobile Orazio, Eduardo; Bonara, Paola; Hu, Cinzia; Spagnol, Giorgio; Radelli, Laura; Scorza Smeraldi, Raffaella.

In: Journal of Neuroimmunology, Vol. 18, No. 3, 1988, p. 207-216.

Research output: Contribution to journalArticle

Della Casa Alberighi, Ornella ; Nobile Orazio, Eduardo ; Bonara, Paola ; Hu, Cinzia ; Spagnol, Giorgio ; Radelli, Laura ; Scorza Smeraldi, Raffaella. / NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin-associated glycoprotein (MAG). In: Journal of Neuroimmunology. 1988 ; Vol. 18, No. 3. pp. 207-216.
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AU - Della Casa Alberighi, Ornella

AU - Nobile Orazio, Eduardo

AU - Bonara, Paola

AU - Hu, Cinzia

AU - Spagnol, Giorgio

AU - Radelli, Laura

AU - Scorza Smeraldi, Raffaella

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