NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients

S Malhotra, M Sorosina, J Río, S Peroni, L Midaglia, LM Villar, JC Álvarez-Cermeño, I Schroeder, F Esposito, F Clarelli, UK Zettl, J Lechner-Scott, N Spataro, A Navarro, G Comi, X Montalban, F Martinelli-Boneschi, M Comabella

Research output: Contribution to journalArticle

Abstract

We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms. These findings do not support a role of polymorphisms located in the NLRP3 gene and the response to IFNβ in MS patients.
Original languageEnglish
Pages (from-to)1507-1510
Number of pages4
JournalMultiple Sclerosis
Volume24
Issue number11
DOIs
Publication statusPublished - 2018

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    Malhotra, S., Sorosina, M., Río, J., Peroni, S., Midaglia, L., Villar, LM., Álvarez-Cermeño, JC., Schroeder, I., Esposito, F., Clarelli, F., Zettl, UK., Lechner-Scott, J., Spataro, N., Navarro, A., Comi, G., Montalban, X., Martinelli-Boneschi, F., & Comabella, M. (2018). NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients. Multiple Sclerosis, 24(11), 1507-1510. https://doi.org/10.1177/1352458517739137