nm23: Unraveling its biological function in cell differentiation

Daniela Lombardi, Marie Lise Lacombe, Marco G. Paggi

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor suppressor genes have a pivotal role in normal cells regulating cell cycle processes negatively. Furthermore, the inhibition of cell proliferation is a crucial step in the achievement of cell differentiation. Increasing evidence suggests that the nm23 genes, initially documented as suppressors of the invasive phenotype in some cancer types, are involved in the control of normal development and differentiation. In this review, we summarize some data concerning the involvement of the nm23 genes in development and differentiation, attempting to delineate an overall view of many facets of their biological role.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalJournal of Cellular Physiology
Volume182
Issue number2
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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