NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease

Matteo Gastaldi; Carla Arbasino; Carlo Dallocchio; Luca Diamanti; Paola Bini; Enrico Marchioni; Diego Franciotta

doi:10.1016/j.jneuroim.2018.12.002

NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease

Matteo Gastaldi, Carla Arbasino, Carlo Dallocchio, Luca Diamanti, Paola Bini, Enrico Marchioni, Diego Franciotta

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article

Abstract

We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. Brain MRI was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Prompt identification and timely immunotherapy led to a complete recovery.

Original language	English
Pages (from-to)	35-37
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	328
DOIs	https://doi.org/10.1016/j.jneuroim.2018.12.002
Publication status	Published - Mar 15 2019

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Gastaldi, M., Arbasino, C., Dallocchio, C., Diamanti, L., Bini, P., Marchioni, E., & Franciotta, D. (2019). NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease. Journal of Neuroimmunology, 328, 35-37. https://doi.org/10.1016/j.jneuroim.2018.12.002

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abstract = "We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. Brain MRI was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Prompt identification and timely immunotherapy led to a complete recovery.",

author = "Matteo Gastaldi and Carla Arbasino and Carlo Dallocchio and Luca Diamanti and Paola Bini and Enrico Marchioni and Diego Franciotta",

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AU - Gastaldi, Matteo

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AU - Dallocchio, Carlo

AU - Diamanti, Luca

AU - Bini, Paola

AU - Marchioni, Enrico

AU - Franciotta, Diego

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AB - We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. Brain MRI was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Prompt identification and timely immunotherapy led to a complete recovery.

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DO - 10.1016/j.jneuroim.2018.12.002

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JO - Journal of Neuroimmunology

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10.1016/j.jneuroim.2018.12.002

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MONDINO - NEUROSCIENZE PRE-CLINICHE E SPERIMENTALI

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NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease

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MONDINO - NEUROSCIENZE PRE-CLINICHE E SPERIMENTALI