Abstract
Human plasma low density lipoprotein has been oxidized at different stages in vitro and analysed by 1H. 13C, and 31P NMR spectroscopy and by biochemical methods. Information was obtained on: a) structure mobilities of lipids and on lipid-protein interactions: b) conjugated and oxo-dienes; c) polyunsaturated/ monounsaturated fatty acid chains; d) lysophosphatidylcholine production. The results show that the NMR approach is particularly useful for the assessment of structural modification in oxidized LDL.
Original language | English |
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Pages (from-to) | 175-183 |
Number of pages | 9 |
Journal | Free Radical Research |
Volume | 8 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1990 |
Keywords
- Ageing
- Atherosclerosis
- Lipid peroxidation
- NMR spectroscopy
- Oxidatively-modified LDL
ASJC Scopus subject areas
- Biochemistry