NMR analysis of low-density lipoprotein oxidatively-modified in vztro

L. Barenghi, S. Bradamante, G. A. Giudici, C. Verganl

Research output: Contribution to journalArticlepeer-review

Abstract

Human plasma low density lipoprotein has been oxidized at different stages in vitro and analysed by 1H. 13C, and 31P NMR spectroscopy and by biochemical methods. Information was obtained on: a) structure mobilities of lipids and on lipid-protein interactions: b) conjugated and oxo-dienes; c) polyunsaturated/ monounsaturated fatty acid chains; d) lysophosphatidylcholine production. The results show that the NMR approach is particularly useful for the assessment of structural modification in oxidized LDL.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalFree Radical Research
Volume8
Issue number3
DOIs
Publication statusPublished - 1990

Keywords

  • Ageing
  • Atherosclerosis
  • Lipid peroxidation
  • NMR spectroscopy
  • Oxidatively-modified LDL

ASJC Scopus subject areas

  • Biochemistry

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