TY - JOUR
T1 - 'No allogeneic blood transfusion' protocol for the surgical correction of craniosynostoses. I. Rationale
AU - Velardi, F.
AU - Di Chirico, A.
AU - Di Rocco, C.
AU - Fundarò, C.
AU - Serafini, R.
AU - Piastra, M.
AU - Viola, L.
AU - Pietrini, D.
AU - Pusateri, A.
AU - Stoppa, F.
PY - 1998
Y1 - 1998
N2 - Improved anesthesiological and surgical care has resulted in a progressively declining need for allogeneic blood transfusion. In infants with craniosynostosis, however, allogeneic blood transfusion is still performed as a routine procedure. In the present paper, the authors describe a protocol they have devised with the aim of limiting or even avoiding allogeneic blood transfusion even in very young patients, consequently avoiding the risks of infective or immunologic reactions associated with the procedure. The protocol is based on stimulation of the hematopoietic system with erythropoietin, selection of an appropriate age for operation when a favorable balance between fetal and adult-type hemoglobin is established (that is after 4-6 months), preoperative preparation of the autologous blood supply, and intraoperative blood salvage.
AB - Improved anesthesiological and surgical care has resulted in a progressively declining need for allogeneic blood transfusion. In infants with craniosynostosis, however, allogeneic blood transfusion is still performed as a routine procedure. In the present paper, the authors describe a protocol they have devised with the aim of limiting or even avoiding allogeneic blood transfusion even in very young patients, consequently avoiding the risks of infective or immunologic reactions associated with the procedure. The protocol is based on stimulation of the hematopoietic system with erythropoietin, selection of an appropriate age for operation when a favorable balance between fetal and adult-type hemoglobin is established (that is after 4-6 months), preoperative preparation of the autologous blood supply, and intraoperative blood salvage.
KW - Allogeneic blood transfusion morbidity
KW - Autologous blood transfusion
KW - Craniosynostosis
KW - Infancy
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U2 - 10.1007/s003810050305
DO - 10.1007/s003810050305
M3 - Article
C2 - 9881626
AN - SCOPUS:0032437857
VL - 14
SP - 722
EP - 731
JO - Child's Nervous System
JF - Child's Nervous System
SN - 0256-7040
IS - 12
ER -